Quinomycin AAn inhibitor of HIF

Quinomycin A (CAS 512-64-1)

Quinomycin A | CAS 512-64-1 is rated 5.0 out of 5 by 1.
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Application: An inhibitor of HIF
CAS Number: 512-64-1
Purity: >99%
Molecular Weight: 1101.3
Molecular Formula: C51H64N12O12S2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Quinomycin A is a cyclodepsipeptide metabolite of the quinoxaline family that exhibits various antibiotic, antiviral, and antitumor activity. Quinomycin A has been demonstrated to bind strongly to DNA at sites containing the central two-base-pair sequence 5'-CG-3'. Quinomycin A was observed to induce apoptosis in human colon cancer cells (HT-29) with activity associated with cytochrome c release and stimulations of ERK and caspase-3. Quinomycin A reportedly inhibits HIF by blocking binding of HIF-1α and HIF-1β proteins to a HRE sequence, and by blocking hypoxic induction of luciferase in U251-HRE cells and VEGF mRNA expression in U251 cells.


References

1. Wakelin, S.P., et al. 1976. Biochem. J. 157: 721-740. PMID: 985413
2. Van Dyke, M.M., et al. 1984. Science. 225: 1122-1127. PMID: 6089341
3. Kong, D., et al. 2005. Cancer Res. 65: 9047-9055. PMID: 16204079
4. Park, J.Y., et al. 2006. Int. J. Biochem. Cell Biol. 38: 244-254. PMID: 16214385

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in DMSO (5 mg/ml), methanol (1 mg/ml), chloroform (10 mg/ml), acetone, dichloromethane, ethyl acetate, 100% ethanol, and DMF. Insoluble in water.
Storage :
Store at -20° C
Boiling Point :
1427.23° C at 760 mmHg (Predicted)
Density :
1.41 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
JW5250000
PubChem CID :
3197
Merck Index :
14: 3497
MDL Number :
MFCD00156105
Beilstein Registry :
78671
SMILES :
CC1C(=O)N(C2CSC(C(C(=O)N(C(C(=O)OCC(C(=O)N1)NC(=O)C3=NC4=CC=CC=C4N=C3)C(C)C)C)N(C(=O)C(NC(=O)C(COC(=O)C(N(C2=O)C)C(C)C)NC(=O)C5=NC6=CC=CC=C6N=C5)C)C)SC)C

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Certificate of Analysis

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Quinomycin A  Product Citations

See how others have used Quinomycin A. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 25862859  Cha, W. et al. 2015. Anticancer Res. 35: 2049-54.

PMID: # 19574634  Pfoh, R. et al. 2009. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65: 660-664.

PMID: # 15177310  Park, JY. et al. 2004. Pharmacol. Res. 50: 201-207.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Quinomycin A was reported in many articles Quinomycin A was reported in many articles of an inhibitor of HIF. -SCBT Publication Review
Date published: 2015-02-20
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