Date published: 2025-12-3

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Quinoline (CAS 91-22-5)

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Alternate Names:
1-Benzazine; 2,3-Benzopyridine
CAS Number:
91-22-5
Molecular Weight:
129.16
Molecular Formula:
C9H7N
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Quinoline is an aromatic heterocyclic organic compound. This compound plays a vital role in the chemical and related industries due to its extensive applications. Quinoline serves as an intermediate in the production of a variety of biologically active substances and contributes to the synthesis of dyes, perfumes, and other materials. It′s also involved in the production of photographic materials. Moreover, it facilitates the synthesis of numerous other organic entities, such as quinoline derivatives, and acts as a fundamental ingredient in the production of quinoline-based substances. Quinoline is used in in vitro experiments, specifically in cell culture systems, and aids in studying cellular processes, including cell proliferation, differentiation, and apoptosis. Furthermore, it contributes to the understanding of drug action mechanisms and the evaluation of the safety and effectiveness of emerging substances. The action mechanism of quinoline remains somewhat unclear. However, it′s suggested that the compound acts as an inhibitor of specific enzymes, like cytochrome P450 enzymes involved in substance metabolism. Additionally, quinoline is believed to disrupt the binding of substances to their receptors.


Quinoline (CAS 91-22-5) References

  1. Quinoline-based antifungals.  |  Musiol, R., et al. 2010. Curr Med Chem. 17: 1960-73. PMID: 20377510
  2. Quinoline--a promising fragment in the search for new antimalarials.  |  Gryzło, B. and Kulig, K. 2014. Mini Rev Med Chem. 14: 332-44. PMID: 24552268
  3. A review on anticancer potential of bioactive heterocycle quinoline.  |  Afzal, O., et al. 2015. Eur J Med Chem. 97: 871-910. PMID: 25073919
  4. Quinoline: a promising antitubercular target.  |  Keri, RS. and Patil, SA. 2014. Biomed Pharmacother. 68: 1161-75. PMID: 25458785
  5. Quinoline-based antimalarial hybrid compounds.  |  Vandekerckhove, S. and D'hooghe, M. 2015. Bioorg Med Chem. 23: 5098-119. PMID: 25593097
  6. Recent Advances in Metal-Free Quinoline Synthesis.  |  Ramann, GA. and Cowen, BJ. 2016. Molecules. 21: PMID: 27483222
  7. Quinoline hybrids and their antiplasmodial and antimalarial activities.  |  Hu, YQ., et al. 2017. Eur J Med Chem. 139: 22-47. PMID: 28800458
  8. Biologically active quinoline and quinazoline alkaloids part I.  |  Shang, XF., et al. 2018. Med Res Rev. 38: 775-828. PMID: 28902434
  9. Biologically active quinoline and quinazoline alkaloids part II.  |  Shang, XF., et al. 2018. Med Res Rev. 38: 1614-1660. PMID: 29485730
  10. Development of Quinoline-Based Theranostic Ligands for the Targeting of Fibroblast Activation Protein.  |  Lindner, T., et al. 2018. J Nucl Med. 59: 1415-1422. PMID: 29626119
  11. Quinoline and quinolone dimers and their biological activities: An overview.  |  Chu, XM., et al. 2019. Eur J Med Chem. 161: 101-117. PMID: 30343191
  12. Quinoline anticancer agents active on DNA and DNA-interacting proteins: From classical to emerging therapeutic targets.  |  Lauria, A., et al. 2021. Eur J Med Chem. 220: 113555. PMID: 34052677
  13. Enzymatic approaches to site-selective oxidation of quinoline and derivatives.  |  Wang, Z., et al. 2022. Org Biomol Chem. 20: 2580-2600. PMID: 35290426

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Quinoline, 5 g

sc-250829
5 g
$41.00

Quinoline, 100 g

sc-250829A
100 g
$37.00