QuercetinA PI 3-kinase inhibitor, GPR30 activator, and apoptosis inducer

Quercetin (CAS 117-39-5)

Quercetin | CAS 117-39-5 is rated 5.0 out of 5 by 1.
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Synonym: Meletin; Sophoretin; 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one
Application: A PI 3-kinase inhibitor, GPR30 activator, and apoptosis inducer
CAS Number: 117-39-5
Purity: ≥95%
Molecular Weight: 302.24
Molecular Formula: C15H10O7
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Quercetin, one of the main flavonoids that exists in galangal (Zingiberaceae), is a hydroxylated flavanoid that has been shown to cause potent reversible inhibition of fatty-acid synthase. It possesses potential antiinflammatory properties. Quercetin also inhibits Trk (tyrosine protein kinase), phospholipase A2, PDE (phosphodiesterases), mitochondrial ATPase, PI 3-kinase and PKC (protein kinase C). It has been reported that the competitive inhibition of FASN by quercetin leads to apoptotic cell death which results in inhibition of cell proliferation. Quercetin also behaves as a GPR30 activator and calcium channel protein inhibitor.


References

1. Li, B.H. and Tian, W.X. 2003. J Enzyme Inhib Med Chem. 18: 349-356. PMID: 14567550
2. Lupu, R. and Menendez, J.A. 2006. Curr Pharm Biotechnol. 7: 483-493. PMID: 17168665
3. Tiong, K.H., et al. 2010. Xenobiotica. 40: 458-466. PMID: 20402563

Physical State :
Solid
Solubility :
Soluble in DMSO (30 mg/ml), DMF (~30 mg/ml), and ethanol (~2 mg/ml).
Storage :
Store at -20° C
Melting Point :
313-318° C
Boiling Point :
642.39° C at 760 mmHg (Predicted)
Density :
1.80 g/cm3 (Predicted)
Refractive Index :
n20D 1.82 (Predicted)
IC50 :
PI 3-kinase: IC50 = 3.8 µM; Aldose Reductase: IC50 = 1.05 ug/ml (human); H9: IC50 = 4 ug/ml (human); Topo IIα: IC50 = 6.9 ug/ml (human); PKC: IC50 = 15 ug/ml
Ki Data :
D4DR: Ki= 7.8 nM (human); Enoyl-acyl-carrier protein reductase: Ki= 22 nM (Plasmodium falciparum); CYP1B1: Ki= 23 nM (human); 5'-nucleotidase: Ki= 45.3 nM (rat); ABCC1: Ki= 0.66 µM (human)
pK Values :
pKa: pK1: 7.17 in phenol (Predicted), pK2: 8.26 in phenol (Predicted), pK3: 10.13 in phenol (Predicted), pK4: 13.11 in phenol (Predicted), pK5: 12.30 in phenol (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
LK8750000
PubChem CID :
5280343
Merck Index :
14: 8034
MDL Number :
MFCD00006828
EC Number :
204-187-1
Beilstein Registry :
317313
SMILES :
C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O

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Quercetin  Product Citations

See how others have used Quercetin. Click on the entry to view the PubMed entry .

Citations 1 to 8 of 8 total

PMID: # 28603085  Fernández-Del-Río, L. et al. 2017. Free Radic. Biol. Med. 110: 176-187.

PMID: # 28949811  Quinney, SK. et al. 2017. Fetal Pediatr Pathol. 36: 400-411.

PMID: # 27697860  Iso, T. et al. 2016. Mol. Cell. Biol. 36: 3100-3112.

PMID: # 27489195  Sak, K. et al. 2016. Food Funct. 7: 3815-24.

PMID: # 26202868  Sadowska-Bartosz, I. et al. 2015. Redox Biol. 6: 93-9.

PMID: # 25354204  2015. Int. J. Cancer. 136: 2304-15.

PMID: # 24296267  Wang, X. et al. 2014. J. Photochem. Photobiol. B, Biol. 130: 47-56.

PMID: # 23949287  Miyagawa, T. et al. 2014. Int. J. Clin. Oncol. 19: 722-30.

Citations 1 to 8 of 8 total

I need to prepare a solution of ethanol (2000ml) of quercetin 117395 concentration 0.01M. what is the mass of quercetin i need to have? and what is the density of quercetin? Thank you.

Asked by: Lux15
Thank you for your question. Our Quercetin product is a solid so there is no density. In order use 2000 ml of ethanol to make 0.01M solution, you would need to add 6.04 g of sc-212920 to get 0.01M.
Answered by: Technical Support
Date published: 2017-01-19

Is this product synthetic?

Asked by: hawkeye11
Thank you for your question. Quercetin, sc-206089, is of plant origin.
Answered by: TechService7
Date published: 2016-12-23
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Rated 5 out of 5 by from Tiong et al Tiong et al. (PubMed ID 20402563) found that quercetin competitively inhibited Coumarin 7-hydroxylase activity via cytochrome P450 2A6 (CYP2A6). -SCBT Publication Review
Date published: 2015-05-01
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