QNZAn inhibitor of the transcription factor NFκB

QNZ (CAS 545380-34-5)

QNZ | CAS 545380-34-5 is rated 5.0 out of 5 by 1.
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Synonym: N4-[2-(4-phenoxyphenyl)ethyl]-4,6-quinazolinediamine;CAY10470
Application: An inhibitor of the transcription factor NFκB
CAS Number: 545380-34-5
Purity: >98%
Molecular Weight: 356.42
Molecular Formula: C22H20N4O
* Refer to Certificate of Analysis for lot specific data (including water content).
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QNZ inhibits the activation of the transcription factor NF-κB and has been used to investigate NF-κB signaling. Improper activation of NF-κB has been linked to cancer, immune and inflammatory diseases, and viral infection. Research results suggest that QNZ fully blocks the increase in K currents in rat sensory neurons. QNZ has been used to study colorectal cancer and Schwann cell functioning.


References

1. Tobe, M., et al. 2003. Bioorg. Med. Chem. 11: 3869-3878. PMID: 12927847
2. Choi, S., et al. 2006. J. Biol. Chem. 281: 12722-12728. PMID: 16490783
3. Armstrong, S.J., et al. 2008. Neurosci. Lett. 439: 42-46. PMID: 18502047
4. Yang, R.H., et al. 2009. Mol Pain. 5: 26. PMID: 19476648
5. Lai, T.Y., et al. 2010. Mol. Cell. Biochem. 342: 63-70. PMID: 20446020

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO (20 mg/ml), DMF (30 mg/ml), ethanol (10 mg/ml), and 1:1 solution DMF:PBS(pH 7.2) (0.5 mg/ml).
Storage :
Store at -20° C
Melting Point :
169-175° C
Boiling Point :
602.00° C at 760 mmHg
Density :
1.28 g/cm3
Refractive Index :
n20D 1.71
IC50 :
TNFα production: IC50 = 7 nM (mouse splenocytes); NF-κB activation: IC50 = 11 nM (human Jurkat cells)
pK Values :
pKb: 5.98
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
509554
SMILES :
C1=CC=C(C=C1)OC2=CC=C(C=C2)CCNC3=NC=NC4=C3C=C(C=C4)N

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Certificate of Analysis

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QNZ  Product Citations

See how others have used QNZ. Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 25609235  Kanayama, M. et al. 2015. Nature communications. 6: 5779.

PMID: # 25622979  Zhao, H. et al. 2015. Molecular cancer. 14: 11.

PMID: # 22033411  Takahashi, N. et al. 2011. Biochemical and biophysical research communications. 415: 200-5.

PMID: # 19120693  Li, L. et al. 2009. J. Cell. Mol. Med. 13: 2684-2692.

PMID: # 19569044  Dasgupta, S. et al. 2009. Int. J. Cancer. 125: 2829-2835.

PMID: # 18718914  Ho, TC. et al. 2008. J. Biol. Chem. 283: 30273-30288.

PMID: # 17057095  deSchoolmeester, ML. et al. 2006. Infect. Immun. 74: 6280-6286.

Citations 1 to 7 of 7 total
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Rated 5 out of 5 by from Kanayama Kanayama, et. al. (PubMed ID 25609235) utilized SCBT product sc-200675, a NFkB inhibitor, in their research regarding NFkB activity. -SCBT Publication Review
Date published: 2015-05-26
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