Qa-1 Antibody (6A8.6F10) is a mouse monoclonal IgG1 (kappa light chain) provided at 200 µg/ml
raised against amino acids 161-179 of mouse Qa-1b
Qa-1 Antibody (6A8.6F10) is recommended for detection of non classical MHC Class I (Class Ib) molecule Qa-1 of mouse origin by WB, IP and FCM
Qa-1 Antibody (6A8.6F10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
azide-free for blocks CTL function, sc-23889 L, 200 µg/0.1 ml
See m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP), our highly recommended recombinant alternative to conventional secondary anti-mouse IgG reagents.
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Qa-1 (6A8.6F10): sc-23889.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Major histocompatibility complex (MHC) molecules, which include human leukocyte antigens (HLAs), are cell-surface receptors that bind foreign peptides and present them to cytotoxic T lymphocytes (CTLs). MHC class I molecules consist of two polypeptide chains, an a or heavy chain, and a non-covalently associated protein, b2-microglobulin. Antigens that bind to MHC class I molecules are typically 8-10 residues in length, and are stabilized in a peptide binding groove. Qa-1, a murine MHC class Ib molecule, presents the Qa-1 determinant modifier (Qdm) peptide to the CD94/NKG2A receptor on natural killer (NK) cells. This interaction participates in protecting self cells by inhibiting NK cytotoxicity, and may be mediated by CD8, since the Qa-1 protein preferentially binds to CD8 (+), but not CD4 (+), T cells. The gene encoding murine Qa-1 maps to chromosome 17.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Can Qa-1 (6A8.6F10): sc-23889 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?
Asked by: AbPolly
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, Qa-1 (6A8.6F10): sc-23889 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
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