PX 12An irreversible and competitive inhibitor of thioredoxin-1

PX 12 (CAS 141400-58-0)

PX 12 | CAS 141400-58-0 is rated 5.0 out of 5 by 1.
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Synonym: 2-[(1-Methylpropyl)dithio]-1H-imidazole
Application: An irreversible and competitive inhibitor of thioredoxin-1
CAS Number: 141400-58-0
Purity: ≥99%
Molecular Weight: 188.31
Molecular Formula: C7H12N2S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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PX 12 is an irreversible and competitive inhibitor of Trx (thioredoxin-1, Trx-1). PX 12 is noted to decrease VEGF, iNOS and HIF-1α, expression. Additionally reported to exhibit antitumor activity and inhibit tubulin polymerization in vitro.


References

1. Kirkpatrick, D.L., et al. 1998. Biochem. Pharmacol. 55: 987-994. PMID: 9605422
2. Welsh, S.J., et al. 2003. Mol. Cancer Ther. 2: 235-243. PMID: 12657718
3. Jordan, B.F., et al. 2005. Clin. Cancer Res. 11: 529-536. PMID: 15701837

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at 4° C
Melting Point :
111.77 °C (Predicted)
Boiling Point :
330.00 °C at 760 mmHg (Predicted)
Density :
1.20 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
HIF-1α: IC50 = 7.2 µM; VEGF: IC50 = ~10 µM; iNOS: IC50 = 18.1 µM
Ki Data :
Trx-1: Ki= 31 µM
pK Values :
pKa: 11.88 (Predicted), pKb: 4.72 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
219104
MDL Number :
MFCD18086851
SMILES :
CCC(C)SSC1=NC=CN1

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Certificate of Analysis

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PX 12  Product Citations

See how others have used PX 12. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 27019135  2016. Biochemical pharmacology. 108: 75-89.

PMID: # 26768768  Pan, H. et al. 2016. Cell Res.

PMID: # 26449594  Zanetti, G. et al. 2015. Biochem. Pharmacol. 98: 522-30.

PMID: # 26550453  Li, GZ. et al. 2015. Am J Transl Res. 7: 1528-40.

PMID: # 24378334  2014. Molecular pharmacology. 85: 460-71.

PMID: # 24718754  Changklungmoa, N. et al. 2014. Parasitol. Res. 113: 2335-43.

Citations 1 to 6 of 6 total
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Rated 5 out of 5 by from Jordan et al Jordan et al. (PubMed ID 15701837) found that the antitumor and thioredoxin-inhibitor, PX 12, caused a rapid decrease in average tumor blood vessel permeability in xenografts. -SCBT Publication Review
Date published: 2015-06-11
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