PTP1B Inhibitor Inhibitor CAS: 765317-72-4
MF: C26H19Br2N3O7S3
MW: 741.5
A protein tyrosine phosphatase 1B enzyme inhibitor.

PTP1B Inhibitor Inhibitor (CAS 765317-72-4)

PTP1B Inhibitor | CAS 765317-72-4 is rated 5.0 out of 5 by 1.
  • y_2020, m_2, d_23, h_18
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_222227, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 141ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Application: A protein tyrosine phosphatase 1B enzyme inhibitor
CAS Number: 765317-72-4
Purity: ≥95%
Molecular Weight: 741.5
Molecular Formula: C26H19Br2N3O7S3
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

PTP1B inhibitor blocks the activity of the PTP1B (Protein Tyrosine Phosphatase 1B), which is a key factor in the negative regulation of insulin and leptin signaling pathway. Molecular dynamic studies have shown that PTP1B inhibitor has strong binding and high selectivity due to the hydrogen bonding networks formed around the active sites. Cytotoxicity and low revival rates throughout clone generation and maintence result if PTP1B is over-expressed in CHO and HEK293 stable cell clones. Studies have shown that PTP1B inhibitor could dramatically magnify the membrane translocation of the key glucose transporter Glut4 in PTP1B-overexpressed CHO cells.


References

1. Sun, T., et al. 2007. Chembiochem. 8: 187-193. PMID: 17183521
2. Wang, J.F., et al. 2009. Protein Eng. Des. Sel. 22: 349-355. PMID: 19380334
3. Xu, J.Q., et al. 2010. Bioorg. Med. Chem. 18: 3934-3939. PMID: 20472439
4. Sundaram, S., et al. 2010. Mol. Biol. 44: 535-540. PMID: 20608179
5. Hughes, S.K. et al. 2015. Mol. Biol. Cell. 26(21): 3867-3878. PMID: 26337385

Physical State :
Solid
Solubility :
Soluble in DMSO, and ethanol.
Storage :
Store at -20° C
Boiling Point :
855° C at 760 mmHg
Density :
1.81 g/cm3
Refractive Index :
n20D 1.73
IC50 :
PTP1B403: IC50 = 4 µM; PTP1B298: IC50 = 8 µM
pK Values :
pKa: 4.47 (Predicted), pKb: 1.70 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
448662
MDL Number :
MFCD09037556
SMILES :
CCC1=C(C2=C(O1)C=C(C=C2)S(=O)(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=NC=CS4)C(=O)C5=CC(=C(C(=C5)Br)O)Br

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

PTP1B Inhibitor Inhibitor  Product Citations

See how others have used PTP1B Inhibitor Inhibitor. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 27016479  Chiba, T. et al. 2016. Biochemical and biophysical research communications. 473: 323-8.

PMID: # 27095436  Song, GJ. et al. 2016. J Neuroinflammation. 13: 86.

PMID: # 26453921  Zhang, H. et al. 2015. Free radical biology & medicine. 89: 701-7.

PMID: # 24519936  Shi, L. et al. 2014. The Journal of biological chemistry. 289: 8432-41.

PMID: # 22903352  Vota, DM. et al. 2013. Cell biochemistry and biophysics. 65: 145-57.

PMID: # 23951017  Zhang, J. et al. 2013. PloS one. 8: e70828.

Citations 1 to 6 of 6 total

What is the IC50 of this product? The website has two different numbers and I am not sure what they designate.

Asked by: SCchem16
Thank you for your question. This chemical, PTP1B Inhibitor: sc-222227, is a non-competitive allosteric inhibitor of PTP1B (IC50 = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively). There are two IC50 values because the inhibitory concentration was measured at two different (assumed) amino acids.
Answered by: Chemical Support 2
Date published: 2017-03-10

What is the half-life period of sc-222227?

Asked by: SCchem16
Thank you for your question. This chemical, PTP1B Inhibitor (CAS 765317-72-4), has a half-life of > 3 years if storage conditions are kept.
Answered by: Chemical Support 2
Date published: 2017-03-10
  • y_2020, m_2, d_23, h_18CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_en_US, sid_222227, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 161ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Hughes Hughes, SK. et al. (PubMed 26337385) report that Mena associates constitutively with the tyrosine phosphatase PTP1B and mediates a novel negative feedback mechanism that attenuates receptor tyrosine kinase signaling. They also found that disruption of this attenuation by MenaINV sensitizes tumor cells to low growth factor concentrations, thereby increasing the migration and invasion responses that contribute to aggressive, malignant cell phenotypes. -SCBT Publication Review
Date published: 2015-05-26
  • y_2020, m_2, d_23, h_18
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_222227, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 9ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.