You may not log in without verifying your email address.
Please check your email (including your spam email) for the Welcome message that was sent.
PTP1B inhibitor blocks the activity of the PTP1B (Protein Tyrosine Phosphatase 1B), which is a key factor in the negative regulation of insulin and leptin signaling pathway. Molecular dynamic studies have shown that PTP1B inhibitor has strong binding and high selectivity due to the hydrogen bonding networks formed around the active sites. Cytotoxicity and low revival rates throughout clone generation and maintence result if PTP1B is over-expressed in CHO and HEK293 stable cell clones. Studies have shown that PTP1B inhibitor could dramatically magnify the membrane translocation of the key glucose transporter Glut4 in PTP1B-overexpressed CHO cells.
1. Sun, T., et al. 2007. Chembiochem. 8: 187-193. PMID: 17183521
2. Wang, J.F., et al. 2009. Protein Eng. Des. Sel. 22: 349-355. PMID: 19380334
3. Xu, J.Q., et al. 2010. Bioorg. Med. Chem. 18: 3934-3939. PMID: 20472439
4. Sundaram, S., et al. 2010. Mol. Biol. 44: 535-540. PMID: 20608179
5. Hughes, S.K. et al. 2015. Mol. Biol. Cell. 26(21): 3867-3878. PMID: 26337385
See how others have used PTP1B Inhibitor Inhibitor. Click on the entry to view the PubMed entry .
PMID: # 27016479 Chiba, T. et al. 2016. Biochemical and biophysical research communications. 473: 323-8.
PMID: # 27095436 Song, GJ. et al. 2016. J Neuroinflammation. 13: 86.
PMID: # 26453921 Zhang, H. et al. 2015. Free radical biology & medicine. 89: 701-7.
PMID: # 24519936 Shi, L. et al. 2014. The Journal of biological chemistry. 289: 8432-41.
PMID: # 22903352 Vota, DM. et al. 2013. Cell biochemistry and biophysics. 65: 145-57.
PMID: # 23951017 Zhang, J. et al. 2013. PloS one. 8: e70828.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.