PTP Inhibitor V, PHPS1 CAS: 314291-83-3
MF: C21H15N5O6S
MW: 465.45
A cell-permeable phosphotyrosine mimetic that acts as an active-site targeting inhibitor of Shp-2.

PTP Inhibitor V, PHPS1 (CAS 314291-83-3)

PTP Inhibitor V, PHPS1 | CAS 314291-83-3 is rated 5.0 out of 5 by 1.
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Alternate Names: PhenylHydrazonoPyrazolone Sulfonate 1
Application: PTP Inhibitor V, PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as an active-site targeting inhibitor of Shp-2
CAS Number: 314291-83-3
Purity: ≥95%
Molecular Weight: 465.45
Molecular Formula: C21H15N5O6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
DISCOUNT: Bulk orders of Chemicals totaling $1,000 or more receive a 5% discount.
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PTP Inhibitor V, PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of Shp-2 (IC50 and Ki = 2.1 and 0.73 µM, respectively). PHPS1 inhibits ECPTP, PTP1B, Shp1, mycobacterium MptpA only at higher concentrations (IC50 = 5.4, 19, 30, and 39 µM, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 µM. PTP Inhibitor V, PHPS1 has been shown to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation.


References

1. Hellmuth, K., et al. 2008. Proc. Natl. Acad. Sci. U.S.A. 105:7275-7280. PMID: 18480264

Usage :
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
Storage :
Store at 4° C
IC50 :
Shp-2: IC50 = 2.1 µM; EC50PTP: IC50 = 5.4 µM; PTP1B: IC50 = 19 µM; Shp1: IC50 = 30 µM; mycobacterium MptpA: IC50 = 39 µM
Ki Data :
Shp-2: Ki= 0.73 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
[S](O)(=O)(=O)CC4=CC=C(NN=C1C(=NN(C1=O)C2=CC=CC=C2)C3=CC=C(C=C3)C[N+]([O-])=O)C=C4

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Certificate of Analysis

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PTP Inhibitor V, PHPS1 (CAS 314291-83-3)  Product Citations

See how others have used PTP Inhibitor V, PHPS1 (CAS 314291-83-3). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 12 total

PMID: # 30776010  Chen, CD. et al. 2019. J. Alzheimers Dis. 67: 1089-1106.

PMID: # 29217681  Ahrendsen, JT.|Harlow, DE.|Finseth, LT.|Bourne, JN.|Hickey, SP.|Gould, EA.|Culp, CM.|Macklin, WB.| et al. 2018. J Neurosci. 38: 787-802.

PMID: # 29498772  Sugimoto, A.|Kataoka, TR.|Ueshima, C.|Takei, Y.|Kitamura, K.|Hirata, M.|Nomura, T.|Haga, H.| et al. 2018. Exp. Dermatol. 27: 641-646.

PMID: # 28947394  Chitranshi, N. et al. 2017. Neuroscience. 364: 175-189.

PMID: # 28445138  Takei, Y.|Ueshima, C.|Kataoka, TR.|Hirata, M.|Sugimoto, A.|Rokutan-Kurata, M.|Moriyoshi, K.|Ono, K.|Murakami, I.|Iwamoto, S.|Haga, H.| et al. 2017. Oncotarget. 8: 36964-36972.

PMID: # 27330052  Zhao, L.|Xia, J.|Li, T.|Zhou, H.|Ouyang, W.|Hong, Z.|Ke, Y.|Qian, J.|Xu, F.| et al. 2016. J Infect Dis. 214: 625-33.

PMID: # 25735953  Ueshima, C.|Kataoka, TR.|Hirata, M.|Furuhata, A.|Suzuki, E.|Toi, M.|Tsuruyama, T.|Okayama, Y.|Haga, H.| et al. 2015. Cancer Immunol Res. 3: 871-80.

PMID: # 23189174  Tsang, YH. et al. 2012. PLoS ONE. 7: -.

PMID: # 22878065  Gupta, VK. et al. 2012. Biochim. Biophys. Acta. 1822: 1643-9.

PMID: # 31598397  Am J Cancer Res. 9: 1957-1969.

Citations 1 to 10 of 12 total
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Rated 5 out of 5 by from Li Li, S. et al. (PubMed 25331952) used the SHP2 inhibitor PHPS1 to demonstrate that SHP2 positively regulates TGF 1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1. -SCBT Publication Review
Date published: 2015-04-10
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