PTP Inhibitor IVA potent, reversible, competitive, & active-site directed inhibitor of PTP

PTP Inhibitor IV (CAS 329317-98-8)

PTP Inhibitor IV | CAS 329317-98-8 is rated 5.0 out of 5 by 1.
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Synonym: bis(4-Trifluoromethylsulfonamidophenyl)-1,4-diisopropylbenzene; Protein Tyrosine Phosphatase Inhibitor IV
Application: A potent, reversible, competitive, & active-site directed inhibitor of PTP
CAS Number: 329317-98-8
Purity: ≥95%
Molecular Weight: 608.61
Molecular Formula: C26H26F6N2O4S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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PTP Inhibitor IV is an uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic which acts as a potent, reversible, competitive, and active-site directed inhibitor of protein tyrosine phosphatases. PTP Inhibitor IV is an inhibitor of PTP β, PTP ε, PTP μ, PTP σ, PTP-MEG, PTP1B and SH-PTP2.


References

1. Huang, Ping., et al., 2003. Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases. Bioorganic & medicinal chemistry. 11(8): 1835-49. PMID: 12659770
2. Shao, Weijian., et al., 2005. Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action. American journal of physiology. Cell physiology. 289(2): C248-56. PMID: 15788487

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), and ACN.
Storage :
Store at 4° C
Boiling Point :
~578.0° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
SHP-2: IC50 = 1.8 µM; PTP1B: IC50 = 2.5 µM; PTP-ε: IC50 = 8.4 µM; PTP-Meg-2: IC50 = 13 µM; PTP-σ: IC50 = 20 µM; PTP-β: IC50 = 6.4 µM; PTP-: IC50 = 6.7 µM
pK Values :
pKa: 4.40 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6420094
MDL Number :
MFCD06660111
SMILES :
CC(C)(C1=CC=C(C=C1)C(C)(C)C2=CC=C(C=C2)NS(=O)(=O)C(F)(F)F)C3=CC=C(C=C3)

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Certificate of Analysis

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PTP Inhibitor IV  Product Citations

See how others have used PTP Inhibitor IV. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 23314616  Kim, EJ. et al. 2013. Inflammation research : official journal of the European Histamine Research Society .. [et al.]. 62: 377-86.

PMID: # 22288587  Lee, SM. et al. 2012. Clinical and experimental immunology. 167: 438-46.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from PTP Inhibitor IV was found to inhibit the PTP Inhibitor IV was found to inhibit the action of lambda protein phosphatase. This was demonstrated by IF showing nuclear localization and increase in signal of phosphorylated NFkB p50 in the treated NIH/3T3 cells. -SCBT QC
Date published: 2015-02-10
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