PTP CD45 Inhibitor is a cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45 (IC50 = 200 nM or 3.8 μM using pNPP or phosphorylated Ick505 peptide as a substrate, respectively). PTP CD45 Inhibitor is not able to effectively inhibit PTPIB (IC50 <30 μM using phosphorylated Ick505 peptide as a substrate). The phenanthrenedione group does not function as a thiol oxidizing agent.
1. Urbanek, R.A., et al. 2001. J. Med. Chem. 44: 1777-1793. PMID: 11356112
Soluble in DMF (10 mg/ml), and DMSO (10 mg/ml).
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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PTP CD45 Inhibitor Inhibitor Product Citations
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PTP CD45 Inhibitor was found to inhibit thePTP CD45 Inhibitor was found to inhibit the action of lambda protein phosphatase. This was demonstrated by IF showing nuclear localization and increase in signal of phosphorylated NFkB p50 in the treated NIH/3T3 cells. -SCBT QC
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