PTP CD45 Inhibitor InhibitorA cell permeable potent reversible inhibitor of CD45

PTP CD45 Inhibitor Inhibitor (CAS 345630-40-2)

PTP CD45 Inhibitor | CAS 345630-40-2 is rated 5.0 out of 5 by 1.
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Synonym: Protein Tyrosine Phosphatase CD45 Inhibitor; N-(9,10-dioxophenanthren-2-yl)-2,2-dimethylpropanamide
Application: A cell permeable potent reversible inhibitor of CD45
CAS Number: 345630-40-2
Purity: ≥97%
Molecular Weight: 307.34
Molecular Formula: C19H17NO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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PTP CD45 Inhibitor is a cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45 (IC50 = 200 nM or 3.8 μM using pNPP or phosphorylated Ick505 peptide as a substrate, respectively). PTP CD45 Inhibitor is not able to effectively inhibit PTPIB (IC50 <30 μM using phosphorylated Ick505 peptide as a substrate). The phenanthrenedione group does not function as a thiol oxidizing agent.


References

1. Urbanek, R.A., et al. 2001. J. Med. Chem. 44: 1777-1793. PMID: 11356112

Physical State :
Solid
Solubility :
Soluble in DMF (10 mg/ml), and DMSO (10 mg/ml).
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9926586
SMILES :
CC(C)(C)C(=O)NC1=CC2=C(C=C1)C3=CC=CC=C3C(=O)C2=O

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Certificate of Analysis

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PTP CD45 Inhibitor Inhibitor  Product Citations

See how others have used PTP CD45 Inhibitor Inhibitor. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24231767  Novák, J. et al. 2014. Molecular immunology. 57: 302-9.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from PTP CD45 Inhibitor was found to inhibit the PTP CD45 Inhibitor was found to inhibit the action of lambda protein phosphatase. This was demonstrated by IF showing nuclear localization and increase in signal of phosphorylated NFkB p50 in the treated NIH/3T3 cells. -SCBT QC
Date published: 2015-02-16
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