PtdIns-(3,4,5)-P3 (1-stearoyl, 2-arachidonoyl) (sodium salt) MF: C47H82O22P4•4Na
MW: 1215
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PtdIns-(3,4,5)-P3 (1-stearoyl, 2-arachidonoyl) (sodium salt)

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Alternate Names: Phosphatidylinositol-3,4,5-triphosphate C-18 (sodium salt)
Molecular Weight: 1215
Molecular Formula: C47H82O22P4•4Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

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The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals.PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and Akts are examples of PtdIns-(3,4,5)-P3-binding proteins. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific PLC. Therefore, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates.


References

1. Lapetina, E.G., et al. 1981. Nature. 292: 367-369. PMID: 626579
2. Majerus, P.W. 1992. Annu. Rev. Biochem. 61: 225-250. PMID: 1323235
3. Tanaka, K., et al. 1997. Eur. J. Biochem. 245: 512-519. PMID: 9151987
4. Yang, X., et al. 1999. J. Biol. Chem. 274: 18973-18980. PMID: 10383396
5. Pike, L.J. and Casey, L. 1996. J. Biol. Chem. 271: 26453-26456. PMID: 8900109
6. Berridge, M.J. 1993. Nature. 361: 315-325. PMID: 8381210

Appearance :
Powder
Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
CCCCCCCCCCCCCCCCCC(OCC(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COP([O-])(O[[email protected]@H]1[[email protected]](O)[[email protected]](OP([O-])(O)=O)[[email protected]@H](OP([O-])(O)=O)[[email protected]](OP([O-])(O)=O)[[email protected]]1O)=O)=O

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Certificate of Analysis

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