PT 1An AMP-activated protein kinase activator

PT 1 (CAS 331002-70-1)

PT 1 | CAS 331002-70-1 is rated 5.0 out of 5 by 2.
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Synonym: 2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoic acid
Application: An AMP-activated protein kinase activator
CAS Number: 331002-70-1
Purity: >98%
Molecular Weight: 497.91
Molecular Formula: C23H16ClN3O6S
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

PT 1 is an AMPK (AMP-activated protein kinase) activator that stimulates AMPK heterotrimer (α1β1γ1) activity (EC50=0.3 μM).

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and 1.1eq. NaOH (100 mM).
Storage :
Store at -20° C
Melting Point :
310.80° C (Predicted)
Boiling Point :
~696.8° C at 760 (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.71 (Predicted)
IC50 :
AMPK heterotrimer(α1β1γ1) : EC5050 = 0.3 µM
pK Values :
pKa: 2.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5753734
SMILES :
CC1=C(C=C(C(=C1)C2=CC=C(O2)/C=C\3/C(=O)N=C(S3)NC4=CC(=C(C=C4)Cl)C(=O)O)[N+](=O)[O-])C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Gu Q Gu Q, Yang X, Lin L, et al. Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting[J]. Hepatology, 2014, 60(6): 1929-1941. PMID: 25130427 <br /> The PT-1 works pretty good in zebrafish!
Date published: 2015-12-28
Rated 5 out of 5 by from Jensen Jensen, TE. et al. (PubMed 25695398) reported that PT-1 selectively activates AMPK- 1 complexes in mouse skeletal muscle, but activates all three subunit complexes in cultured human cells by inhibiting the respiratory chain. -SCBT Publication Review
Date published: 2015-02-01
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