PSB 603An antagonist of the Adenosine A2B-R

PSB 603 (CAS 1092351-10-4)

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Synonym: 8-[4-[4-(4-Chlorophenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine
Application: An antagonist of the Adenosine A2B-R
CAS Number: 1092351-10-4
Purity: ≥98%
Molecular Weight: 529.01
Molecular Formula: C24H25ClN6O4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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PSB 603 is an Adenosine A2B-R antagonist that displays > 17000-fold selectivity over other Adenosine A Receptors (Ki values are 0.568, > 10000, > 10000 and > 10000 nM for Adenosine A2B-R, Adenosine A1-R, Adenosine A2A-R and Adenosine A3-R, respectively).

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mM).
Storage :
Store at 4° C
Density :
1.43 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
Adenosine A2B-R: IC50 = 1.13 nM (human)
Ki Data :
Adenosine A2B-R: Ki= 0.55 nM (human); Adenosine A1-R: Ki= >10 µM (human); Adenosine A3-R: Ki= >10 µM (human); Adenosine A1 receptor: Ki= > 10 µM (rat); Adenosine A2a receptor: Ki= > 10 µM (rat)
pK Values :
pKa: 7.37 (Predicted), pKb: 4.05 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
44185871
MDL Number :
MFCD11519964
SMILES :
CCCN1C(=O)C2=C(NC1=O)N=C(N2)C3=CC=C(C=C3)S(=O)(=O)N4CCN(CC4)C5=CC=C(C=C5)Cl

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Certificate of Analysis

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