PSB 36 is a potent and selective Adenosine A1-R antagonist. PSB 36 displays binding affinities of 0.12, 187, 552, 6500 and 2300 nM for rat Adenosine A1-R, human Adenosine A2B-H, rat Adenosine A2A-R, rat Adenosine A3-R and human Adenosine A3-H, respectively. This compound demonstrates greater selectivity than DPCPX.
1. Abo-Salem, O.M., et al. 2004. J. Pharmacol. Exp. Ther. 308: 358-366. 2. Weyler, S., et al. 2006. Chem. Med. Chem. 1: 891-902.
Soluble in DMSO (100 mM), and ethanol (100 mM).
Desiccate at 4° C
646.01° C at 760 mmHg (Predicted)
1.30 g/cm3 (Predicted)
n20D 1.62 (Predicted)
Adenosine A1-R: Ki= 0.16 nM (human)
pKa: 9.17 (Predicted), pKb: 2.49 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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