PSB 36A potent Adenosine A1-R antagonist

PSB 36 (CAS 524944-72-7)

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Synonym: 1-butyl-8-(3-noradamantyl)-3-(3-hydroxypropyl)xanthine
Application: A potent Adenosine A1-R antagonist
CAS Number: 524944-72-7
Purity: ≥98%
Molecular Weight: 386.49
Molecular Formula: C21H30N4O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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PSB 36 is a potent and selective Adenosine A1-R antagonist. PSB 36 displays binding affinities of 0.12, 187, 552, 6500 and 2300 nM for rat Adenosine A1-R, human Adenosine A2B-H, rat Adenosine A2A-R, rat Adenosine A3-R and human Adenosine A3-H, respectively. This compound demonstrates greater selectivity than DPCPX.


References

1. Abo-Salem, O.M., et al. 2004. J. Pharmacol. Exp. Ther. 308: 358-366.
2. Weyler, S., et al. 2006. Chem. Med. Chem. 1: 891-902.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (100 mM).
Storage :
Desiccate at 4° C
Melting Point :
<182° C
Boiling Point :
646.01° C at 760 mmHg (Predicted)
Density :
1.30 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
Ki Data :
Adenosine A1-R: Ki= 0.16 nM (human)
pK Values :
pKa: 9.17 (Predicted), pKb: 2.49 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11689583
MDL Number :
MFCD08703092
SMILES :
CCCCN1C(=O)C2=C(N=C(N2)C34CC5CC(C3)CC4C5)N(C1=O)CCCO

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Certificate of Analysis

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PSB 36  Product Citations

See how others have used PSB 36. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27510152  Liu, C.|Skaldin, M.|Wu, C.|Lu, Y.|Zavialov, AV.| et al. 2016. Sci Rep. 6: 31370.

Citations 1 to 1 of 1 total
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