PSB 10 is a potent and highly selective antagonist for the human Adenosine A3-R, with low affinity for the rat Adenosine A3-R (Ki values are 0.44 and > 17000 nM, respectively). PSB 10 Displays > 3800-fold selectivity over human Adenosine A1-R, Adenosine A2A-R and Adenosine A2B-R (Ki values are 4.1, 3.3 and 30 μM, respectively) and > 1800-fold selectivity over rat Adenosine A1-R and Adenosine A2A-R. This compound acts as an inverse agonist in the [35S]GTPγS binding assay in hA3-CHO cells (IC50 = 4 nM).
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