PSB 10 hydrochlorideCAS: 591771-91-4
MF: C16H14Cl3N5O•HCl
MW: 435.14
A potent and highly selective antagonist for the Adenosine A3-R.

PSB 10 hydrochloride (CAS 591771-91-4)

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Synonym: 8-Ethyl-1,4,7,8-tetrahydro-4-methyl-2-(2,3,5-trichlorophenyl)-5H-imidazo[2,1-i]purin-5-one monohydrochloride
Application: A potent and highly selective antagonist for the Adenosine A3-R
CAS Number: 591771-91-4
Molecular Weight: 435.14
Molecular Formula: C16H14Cl3N5O•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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PSB 10 is a potent and highly selective antagonist for the human Adenosine A3-R, with low affinity for the rat Adenosine A3-R (Ki values are 0.44 and > 17000 nM, respectively). PSB 10 Displays > 3800-fold selectivity over human Adenosine A1-R, Adenosine A2A-R and Adenosine A2B-R (Ki values are 4.1, 3.3 and 30 μM, respectively) and > 1800-fold selectivity over rat Adenosine A1-R and Adenosine A2A-R. This compound acts as an inverse agonist in the [35S]GTPγS binding assay in hA3-CHO cells (IC50 = 4 nM).


References

1. Muller, C.E. 2003. Curr. Top. Med. Chem. 3: 445-462.
2. Ozola, V., et al. 2003. Bioorg. Med. Chem. 11: 347-356.
3. Abo-Salem, O.M., et al. 2004. J. Pharmacol. Exp. Ther. 308: 358-366.

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mM), and ethanol (10 mM).
Storage :
Desiccate at 4° C
Refractive Index :
n20D ~1.77 (Predicted)
IC50 :
[35S]GTPγS binding assay in hA3-CHO cells: IC50 = 4 nM
Ki Data :
Adenosine A3-R: Ki= 0.44 nM (human); Adenosine A2A-R: Ki= 3.3 µM (human); Adenosine A1-R: Ki= 4.1 µM (human); Adenosine A3 receptor: Ki= >17 µM (rat); Adenosine A2B-R: Ki= 30 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
90488733
SMILES :
CC[[email protected]@H]1CN2C(=N1)C3=C(N=C(N3)C4=CC(=CC(=C4Cl)Cl)Cl)N(C2=O)C.Cl

Download SDS (MSDS)

Certificate of Analysis

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