PSB 0788A potent and selective Adenosine A2B-R antagonist

PSB 0788 (CAS 1027513-54-7)

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Synonym: 8-[4-[4-(4-Chlorobenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine
Application: A potent and selective Adenosine A2B-R antagonist
CAS Number: 1027513-54-7
Molecular Weight: 543.04
Molecular Formula: C25H27ClN6O4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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PSB 0788 is a potent and selective Adenosine A2B-R antagonist (IC50 = 3.64 nM at human Adenosine A2B-R). It displays > 100-fold selectivity over human Adenosine A1-R, human Adenosine A2A-R and human Adenosine A3-R.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at 4° C
Density :
1.41 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
Adenosine A2B-R: IC50 = 3.64 nM (human)
Ki Data :
Adenosine A2B-R: Ki= 0.39 nM (human); Adenosine A1 receptor: Ki= 386 nM (rat); Adenosine A3-R: Ki>1 µM (human); Adenosine A2a receptor: Ki= 1.73 µM (rat); Adenosine A1-R: Ki= 2.24 µM (human)
pK Values :
pKa: 7.37 (Predicted), pKb: 5.05 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
44186581
MDL Number :
MFCD09971120
SMILES :
CCCN1C(=O)C2=C(NC1=O)N=C(N2)C3=CC=C(C=C3)S(=O)(=O)N4CCN(CC4)CC5=CC=C(C=C5)Cl

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Certificate of Analysis

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Asked by: tkht
Thank you for your question. Please contact our local distributors in Japan to confirm the price and lead time. The contact information can be found below. https://www.scbt.com/scbt/resources/distributors お問い合わせを頂きまして、誠にありがとうございました。お手数ですが、日本での購入は弊社の日本での代理店へお勧めします。納期と日本円での価格は代理店へご連絡ください。 代理店は下記の四社となります。 https://www.scbt.com/scbt/resources/distributors
Answered by: Technical Support 8
Date published: 2017-06-20
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