PSB 06126A selective inhibitor of NTPDase 3

PSB 06126 (CAS 1052089-16-3)

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Synonym: 1-Amino-4-(1-naphthyl)aminoanthraquinone-2-sulfonic acid sodium salt
Application: A selective inhibitor of NTPDase 3
CAS Number: 1052089-16-3
Purity: ≥98%
Molecular Weight: 466.44
Molecular Formula: C24H15N2NaO5S
* Refer to Certificate of Analysis for lot specific data (including water content).
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PSB 06126 is a CD39L3 (nucleoside triphosphate diphosphohydrolase 3, NTPDase 3) inhibitor. This compound has been reported to inhibit rat NTPDase 3 at low micromolar concentrations and display selectivity over NTPDase 1 and NTPDase 2.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (50 mM).
Storage :
Store at room temperature
Refractive Index :
n20D ~1.78 (Predicted)
IC50 :
P2Y2: IC50 = 6.67 µM (human); P2Y4: IC50 = 10.1 µM (human); P2Y6: IC50 = 30 µM (rat)
Ki Data :
5'-nucleotidase: Ki= 0.53 µM (rat); Nucleoside triphosphate diphosphohydrolase 3: Ki= 1.5 µM (rat); Purinergic receptor P2Y12: Ki= >10 µM (human); Ectonucleoside triphosphate diphosphohydrolase 1: Ki= >150 µM (rat); Ectonucleoside triphosphate diphosphohydrolase 2: Ki= >400 µM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
24868313
MDL Number :
MFCD09971095
SMILES :
C1=CC=C2C(=C1)C=CC=C2NC3=CC(=C(C4=C3C(=O)C5=CC=CC=C5C4=O)N)S(=O)(=O)[O-].[Na+]

Download SDS (MSDS)

Certificate of Analysis

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