Psammaplin A is an antibiotic, anti-tumor, DNA methyltransferase (Dnmt) inhibitor. It is a bromotyrosine-derived, symmetrical conjugate of cystamine, which was first isolated from the Psammaplinaplysilla sponge. Impedes angiogenesis as well as bacterial and tumor cell growth. Inhibits the activities of several key enzymes in prokaryotic and eukaryotic systems including those involved in epigenetic control of gene expression, DNA replication, angiogensis, and microbial detoxification.
1. Kim, T.H. et al. 2015. Biochim. Biophys. Acta. 1850(2): 401-410. PMID: 25445714
See how others have used Psammaplin A. Click on the entry to view the PubMed entry .
PMID: # 27497787 Al Mamun Bhuyan, A. et al. 2016. Cell. Physiol. Biochem. 39: 908-18.
PMID: # 26621919 Mallol, A. et al. 2016. Reproduction. 151: 203-14.
PMID: # 25749170 Mallol, A. et al. 2015. PLoS ONE. 10: e0120033.
PMID: # 25445714 Kim, TH. et al. 2015. Biochimica et biophysica acta. 1850: 401-10.
PMID: # 25068567 Mallol, A. et al. 2014. Cell Reprogram. 16: 392-406.
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