Protein Kinase Inhibitor, DMAPA non selective inhibitor of cdc2/cyclin B

Protein Kinase Inhibitor, DMAP (CAS 938-55-6)

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Synonym: N(6),N(6)-dimethyladenine
Application: A non selective inhibitor of cdc2/cyclin B
CAS Number: 938-55-6
Purity: >98%
Molecular Weight: 163.18
Molecular Formula: C7H9N5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Protein Kinase Inhibitor, DMAP is a puromycin analog that acts as a protein kinase inhibitor. Selectively induces premature mitosis in mammalian cells. Inhibits TNF-α upregulation of ICAM-1, lipolysis, and the activation of JNK/SAPK. Inhibits p34cdc2/cyclin B (IC50 = 300 µM). Induces apoptosis in S-phase-arrested HeLa cells (~5 mM).


References

1. Neant, I., et al. 1988. Exp. Cell Res. 176: 68-79. PMID: 2836230
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3. Aghion, J., et al. 1994. J. Cell. Sci. 107: 1369-1379. PMID: 7929642
4. Meikrantz, W., et al. 1994. Proc. Natl. Acad. Sci. U.S.A. 91: 3754-3758. PMID: 8170983
5. Ajiro, K., et al. 1996. J. Biol. Chem. 271: 13197-13201. PMID: 8662672
6. Marino, M.W., et al. 1996. J. Biol. Chem. 271: 28624-28629. PMID: 8910494
7. De Cesaris, P., et al. 1999. J. Biol. Chem. 274: 28978-28982. PMID: 10506145
8. Flament, S., et al. 2000. Zygote. 8: 3-14. PMID: 10840869
9. Ryden, M., et al. 2002. J. Biol. Chem. 277: 1085-1091. PMID: 11694522
10. Im, G.S., et al. 2007. Mol. Reprod. Dev. 74: 1158-1164. PMID: 17366547
11. Nakashima, M., et al. 2008. Anticancer Res. 28: 609-620. PMID: 18506999

Physical State :
Solid
Solubility :
Dilute Acids or H2O
Storage :
Store at 4° C
Melting Point :
251-253° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
US9230000
PubChem CID :
3134
MDL Number :
MFCD00005573
EC Number :
213-344-3
Beilstein Registry :
7634
SMILES :
CN(C)C1=NC=NC2=C1NC=N2

Download SDS (MSDS)

Certificate of Analysis

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