Proteasome Inhibitor VII, AntiprotealideInactivates the β5-subunit of the human 20S proteasome

Proteasome Inhibitor VII, Antiprotealide

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Application: Inactivates the β5-subunit of the human 20S proteasome
Purity: ≥95%
Molecular Weight: 275.7
Molecular Formula: C12H18ClNO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Proteasome Inhibitor VII, Antiprotealide is a cell-permeable, Omuralide-Salinosporamide hybrid that irreversibly inactivates the β5-subunit of the human 20S proteasome. The compound has shown to be ~2.5-fold more potent than Omuralide and is expected to exhibit comparable whole cell potency to Salinosporamide A.


References

1. Reddy, Leleti Rajender., et al., 2005. An efficient, stereocontrolled synthesis of a potent omuralide-salinosporin hybrid for selective proteasome inhibition. Journal of the American Chemical Society. 127(25): 8974-6. PMID: 15969573

Physical State :
Solid
Solubility :
Soluble in DMSO.
Storage :
Store at -80° C
Melting Point :
194.33° C (Predicted)
Boiling Point :
484.69° C at 760 mmHg (Predicted)
Density :
1.31 g/cm3 (Predicted)
Refractive Index :
n20D 1.53 (Predicted)
IC50 :
chymotrypsin-like activity of 20S proteasome: IC50 = 27 nM (rabbit ); trypsin-like activity of 20S proteasome: IC50 = 211 nM (rabbit); RPMI8226 cells: IC50 = 220 nM (human)
pK Values :
pKa: 13.27 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11173422
SMILES :
CC(C)[C@@H]([C@]12C(=O)O[C@]1([C@H](C(=O)N2)CCCl)C)O

Download SDS (MSDS)

Certificate of Analysis

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