Proteasome Inhibitor II MF: C29H39N3O5
MW: 509.7
A potent, cell-permeable, and reversible proteasome inhibitor.

Proteasome Inhibitor II

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Synonym: Z-LLF-CHO
Application: A potent, cell-permeable, and reversible proteasome inhibitor
Purity: ≥95%
Molecular Weight: 509.7
Molecular Formula: C29H39N3O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Proteasome Inhibitor II is a potent, cell-permeable, reversible proteasome inhibitor. The compound has been shown to inhibit chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (MPC; Ki = 460 nM). Proteasome Inhibitor II blocks the decay of IkB-a and IkB-b proteins in exponentially growing WEHI 231 cells. The chemical has been shown not to inhibit the peptidyl-glutamyl peptide hydrolyzing activity of MPC at concentrations as high as 200 µM.


1. Orlowski, M., et al., 1993. Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids. Biochemistry. 32(6): 1563-72. PMID: 8431436
2. Orlowski, M., et al., 1997. Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes). Biochemistry. 36(45): 13946-53. PMID: 9374874
3. Schauer, S L., et al., 1998. Dominant signals leading to inhibitor kappaB protein degradation mediate CD40 ligand rescue of WEHI 231 immature B cells from receptor-mediated apoptosis. Journal of immunology (Baltimore, Md. : 1950). 160(9): 4398-405. PMID: 9574544

Physical State :
Solubility :
DMSO (5 mg/ml)
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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Proteasome Inhibitor II  Product Citations

See how others have used Proteasome Inhibitor II. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25461257  Aveic, S. et al. 2015. Exp. Hematol. 43: 180-190.e6.

Citations 1 to 1 of 1 total
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