ProstratinA PKC (Protein Kinase C) activator and potential HIV infection inhibitor

Prostratin (CAS 60857-08-1)

Prostratin | CAS 60857-08-1 is rated 4.0 out of 5 by 2.
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Synonym: 12-Deoxyphorbol-13-Acetate
Application: A PKC (Protein Kinase C) activator and potential HIV infection inhibitor
CAS Number: 60857-08-1
Purity: ≥98%
Molecular Weight: 390.47
Molecular Formula: C22H30O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Prostratin is a PKC (Protein Kinase C) activator that does not induce tumor formation. It upregulates latent HIV-1 provirus expression and inhibts HIV infection and viral spread at the entry/fusion step of viral life cycle. This essentially helps the body rid the latently infected CD4+ T-cells of the virus. Theoretically when used with other drugs (in vitro) this could eliminate the virus from latent and active life cycles completely. Prostratin is an activator of IKK. The compound was interestingly discovered from an ethnobotanical studies on Samoa. It was originally discovered in the tree Homolanthus nutans of which was known to be useful to scientific research on viruses.


References

1. Zayed, S., et al. 1977. Experientia. 33: 1554-1555. PMID: 590432
2. Szallasi, Z., et al. 1993. Cancer Res. 53: 2507-2512. PMID: 8495413
3. Williams, S.A., et al. 2004. J. Biol. Chem. 279: 42008-42017. PMID: 15284245
4. Hezareh, M. 2005. Drug News Perspect. 18: 496-500. PMID: 16391719
5. Sung, T.L. and Rice, A.P. 2006. Retrovirology. 3: 66. PMID: 17014716

Physical State :
Solid
Solubility :
Soluble in DMSO (30 mg/ml), 100% ethanol (25 mg/ml), and DMF (~10 mg/ml).
Storage :
Store at -20° C
Melting Point :
216-219° C
Boiling Point :
550.50° C at 760 mmHg (Predicted)
Density :
1.31 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
IC50 :
Human immunodeficiency virus 1: EC5050 = 0.06 nM; Sindbis virus: EC5050 = >256 µM; Semliki forest virus: EC5050 = >256 µM; Ramos B cells: IC50 = 0.06 ug/ml (human); KB cells: IC50 = 1000 ug/ml (human)
Ki Data :
Protein kinase C α: Ki= 4.8 nM (Bos taurus); PKC: Ki= 190 nM (human)
pK Values :
pKa: 11.4 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
454217
MDL Number :
MFCD00674138
SMILES :
C[C@@H]1C[C@@]2([C@@H](C2(C)C)[C@H]3[C@]1([C@@H]4C=C(C(=O)[C@]4(CC(=C3)CO)O)C)O)OC(=O)C

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Certificate of Analysis

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Prostratin  Product Citations

See how others have used Prostratin. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 18 total

PMID: # 30764849  Pérez-Fernández, A. et al. 2019. J. Exp. Clin. Cancer Res. 38: 80.

PMID: # 29170390  Fong, LE. et al. 2017. Sci Rep. 7: 16179.

PMID: # 28368303  Jean, MJ. et al. 2017. Viruses. 9:

PMID: # 28819452  Chen, L. et al. 2017. Theranostics. 7: 2634-2648.

PMID: # 28638377  Huang, H. et al. 2017. Front Microbiol. 8: 1035.

PMID: # 27529070  Chen, D. et al. 2016. Biomed Res Int. 2016: 5173205.

PMID: # 26728316  Chan, CN. et al. 2016. Retrovirology. 13: 1.

PMID: # 27731641  Tsai, JY. et al. 2016. J. Nat. Prod. 79: 2658-2666.

PMID: # 26151856  Nothias-Scaglia, LF. et al. 2015. Fitoterapia. 105: 202-9.

PMID: # 26378236  Huang, H. et al. 2015. The Journal of biological chemistry. 290: 27297-310.

Citations 1 to 10 of 18 total

Is Prostratin now available to the public for consumption or is it for research and testing only?

Asked by: Dumisa
Thank you for your inquiry. All of our products are for research use only, and are research grade not food grade and are not recommended for consumption. They are not to be used in any production, therapeutic or diagnostic application.
Answered by: Tech Service
Date published: 2017-02-14
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Rated 4 out of 5 by from It worked well in my experiments It worked well in my experiments, will order another vial soon.
Date published: 2015-06-02
Rated 4 out of 5 by from No comment No comment
Date published: 2015-03-19
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