Prostaglandin I2 sodiumAn eiconasoid shown to induce vasodilation and inhibit platelet aggregation

Prostaglandin I2 sodium (CAS 61849-14-7)

Prostaglandin I2 sodium | CAS 61849-14-7 is rated 5.0 out of 5 by 3.
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Synonym: 6,9α-epoxy-11α,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid, monosodium salt; Epoprostenol sodium salt; PGI2•Na
Application: An eiconasoid shown to induce vasodilation and inhibit platelet aggregation
CAS Number: 61849-14-7
Purity: ≥98%
Molecular Weight: 374.45
Molecular Formula: C20H31O5•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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PGI2·Na (Prostaglandin I2·Na, Prostacyclin) is primarily synthesized in macrovascular endothelial cells. It has been shown to induce vasodilation, inhibit platelet aggregation, as well as demonstrate fibrinolytic and cytoprotective activity. PGI2 binding to the G-protein coupled IP1 receptor (PGI2 receptor), is believed to be responsible for the inhibition of platelet aggregation and vasodilation activity. PGI2 greatly increases cAMP concentrations, it is 30 times more active than PGE1(sc-201223), and 10 times more active than PGD2(sc-201221); however, it is a relatively unstable eicosanoid, with a half-life of about 2 minutes under physiological conditions. Analogues such as Iloprost (sc-205349) have been developed with superior stability and similar potency for IP receptors. PGI2·Na (Prostaglandin I2·Na, Prostacyclin) is an activator of IP Receptor and an inhibitor of TXA2R.


References

1. Weksler, B.B., et al. 1977. Proc. Natl. Acad. Sci. U.S.A. 74: 3922-3926. PMID: 333448
2. Tateson, J.E., et al. 1977. Prostaglandins. 13: 389-397. PMID: 191877
3. Coleman, R.A., et al. 1994. Pharmacol. Rev. 46: 205-229. PMID: 7938166
4. Gryglewski, R.J. 1995. Pol J Pharmacol. 47: 467-472. PMID: 8868142
5. Tanaka, Y., et al. 2004. Curr Med Chem Cardiovasc Hematol Agents. 2: 257-265. PMID: 15320791
6. Shah, B.H. 2005. Trends Endocrinol. Metab. 16: 199-201. PMID: 15950485

Physical State :
Solid
Derived From :
Synthetic
Solubility :
Soluble in water (>11 mg/ml) at 25° C, DMSO (30 mg/ml), ethanol (50 mg/ml), and PBS pH 7.2.
Storage :
Store at -20° C
IC50 :
platelet aggregation: IC50 = 5 nM (human); Rattus norvegicus: IC50 = 3.4 ng/ml
pK Values :
pKa: 4.70
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
23702145
Merck Index :
14: 07875
MDL Number :
MFCD00135629
EC Number :
263-273-7
Beilstein Registry :
6472195
SMILES :
CCCCC[C@@H](/C=C/[C@H]1[C@@H](C[C@H]2[C@@H]1/C(=C\\CCCC(=O)[O-])/CO2)O)O.[Na+]

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Certificate of Analysis

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Prostaglandin I2 sodium  Product Citations

See how others have used Prostaglandin I2 sodium. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 15358690  Humbert, M. et al. 2004. Eur. Respir. J. 24: 353-359.

PMID: # 10462369  Krowka, MJ. et al. 1999. Hepatology. 30: 641-648.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from 功能有待证实 邮寄速度很快,包装很好,客服也很给力,解答到位,解释清楚。产品包装裹得特别严实,小瓶外面有两层logo,只是说明书感觉内容少了些,文献说PGI2很容易降解,但是PGI2Na是不是也这样并没有任何说明,也没有提供最稳定的溶解方式,只提供了最大溶解度
Date published: 2017-11-13
Rated 5 out of 5 by from 功能有待证实 邮寄速度很快,包装很好,客服也很给力,解答到位,解释清楚。产品包装裹得特别严实,小瓶外面有两层logo,只是说明书感觉内容少了些,文献说PGI2很容易降解,但是PGI2Na是不是也这样并没有任何说明,也没有提供最稳定的溶解方式,只提供了最大溶解度
Date published: 2017-11-13
Rated 5 out of 5 by from Humbert et al Humbert et al. (PubMed ID 15358690) used PGI2 Na (Prostaglandin I2 Na, Prostacyclin), a vasodilator, to relax pulmonary vascular resistance, which improved survival of patients with pulmonary arterial hypertension. -SCBT Publication Review
Date published: 2015-01-20
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