Proscillaridin AA cardiac glycoside and sodium/potassium ATPase inhibitor

Proscillaridin A (CAS 466-06-8)

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Synonym: 3-(6-Deoxy-α-L-mannopyranosyloxyl)-14-hydroxybufa-4,20,22-trienolide; Scillarenin 3β-rhamnoside
Application: A cardiac glycoside and sodium/potassium ATPase inhibitor
CAS Number: 466-06-8
Purity: ≥90%
Molecular Weight: 530.66
Molecular Formula: C30H42O8
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Proscillaridin A is a cardiac glycoside which functions as a specific Na+/K+-ATPase inhibitor. It is reported that at high concentrations, above 300nM, Proscillaridin A can increase intracellular Ca2+ concentration, activate caspase-3 and induce apoptosis in human fibroblasts. However in low concentrations Proscillaridin A can activate the proliferation of fibroblasts. Studies suggest that Proscillaridin A inhibits both topoisomerase I and II activity simultaneously resulting in cytotoxicity of MCF-7 cells (sc-2206). In addition, Proscillaridin A is more effective at MCF-7 cell proliferation than other cardiac glycosides such as digoxin and ouabain (sc-201548).

Physical State :
Solid
Storage :
Store at 4° C
Boiling Point :
~716.7° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
16219784
SMILES :
C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2CCC3(C4CCC5(C(CCC5(C4CCC3=C2)O)C6=COC(=O)C=C6)C)C)O)O)O

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Certificate of Analysis

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