Propranolol hydrochlorideCAS: 3506-09-0
MF: C16H21NO2•HCl
MW: 295.80
A β1 and β2 adrenergic receptor blocker.

Propranolol hydrochloride (CAS 3506-09-0)

Propranolol hydrochloride | CAS 3506-09-0 is rated 5.0 out of 5 by 1.
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Synonym: (±)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride
Application: A β1 and β2 adrenergic receptor blocker
CAS Number: 3506-09-0
Purity: ≥97%
Molecular Weight: 295.80
Molecular Formula: C16H21NO2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Propranolol hydrochloride is a cationic amphiphillic molecule shown to block β1 and β2 adrenergic receptors with similar efficacy, without affecting α adrenergic receptors. Demonstrates high affinity for SR-1B (5-HT1B) receptors (Ki = 17nM), and milder affinity for SR-1D (5HT-1D) receptors (Ki = 10.2 μM). Propranolol hydrochloride also has been shown to inhibit the formation of phospholipase D-derived diacylglycerol (DAG) by inhibiting cytosolic phosphatidate phosphohydrolase; making propranolol a useful tool for investigating phospholipase D-, and phospholipase C-mediated DAG production. Propranolol hydrochloride is an inhibitor of AR.


References

1. Pappu, A.S. and Hauser, G. 1983. Neurochem. Res. 8: 1565-1575. PMID: 6324013
2. Thompson, N.T., et al. 1991. Trends Pharmacol. Sci. 12: 404-408. PMID: 1665608
3. Fujita, K., et al. 1996. FEBS Lett. 395: 293-298. PMID: 8898114
4. Glennon, R.A., et al. 1996. Mol. Pharmacol. 49: 198-206. PMID: 8569707

Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), ethanol (10 mg/ml), DMSO (<14.5 mg/ml), and methanol.
Storage :
Store at -20° C
Melting Point :
163-165° C
Boiling Point :
434.9° C at 760 mmHg (Predicted)
Ki Data :
5HT-1B receptors: Ki= 17 nM; 5HT-1D receptors: Ki= 10.2 µM
pK Values :
pKa: 9.5 (24° C), 13.84 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UB7525000
PubChem CID :
62882
Merck Index :
14: 7840
MDL Number :
MFCD00012558
EC Number :
206-268-7
Beilstein Registry :
4164259
SMILES :
CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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Propranolol hydrochloride  Product Citations

See how others have used Propranolol hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 25743758  Verplaetse, TL. et al. 2015. Psychopharmacology (Berl.). 232: 2647-57.

PMID: # 20150590  Haack, KK. et al. 2010. J Biomol Screen. 15: 251-260.

PMID: # 20147605  Baum, M. et al. 2010. Am. J. Physiol. Regul. Integr. Comp. Physiol. 298: R954-R958.

PMID: # 19925788  Li, J. et al. 2010. Exp. Mol. Pathol. 88: 32-37.

PMID: # 18837991  Karavolos, MH. et al. 2008. BMC Genomics. 9: -.

PMID: # 18621717  Shukla, AK. et al. 2008. Proc. Natl. Acad. Sci. U.S.A. 105: 9988-9993.

Citations 1 to 6 of 6 total
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Rated 5 out of 5 by from Li et al Li et al. (PubMed ID 19925788) found that Propranolol hydrochloride, a beta adrenergic blocker, changed the rate of ethanol elimination by blocking the blood alcohol (BAL) cycle in rats. -SCBT Publication Review
Date published: 2015-02-16
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