PRIMA-1MET is a methylated derivative of PRIMA-1 (sc-200927). This compound has been shown to restore mutant p53 activity, and to act synergistically with chemotherapeutic agents to inhibit tumor cell proliferation. PRIMA-1MET is an inhibitor of Trx and an activator of p53.
1. Bykov, Vladimir J N., et al., 2005. PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis. Oncogene. 24(21): 3484-91. PMID: 15735745
2. Shen, J., et al., 2008. PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2. Oncogene. 27(51): 6571-80. PMID: 18663359
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SobhaniSobhani, M. et al. (PubMed 25803193) evaluated the anti-tumor activity of PRIMA-1MET in Waldenstr m's Macroglobulinemia (WM) cell lines. Treatment with PRIMA-1MET resulted in induction of apoptosis, inhibition of migration and suppression of colony formation. Upon PRIMA-1MET treatment, p73 was upregulated and Bcl-xL was down-regulated while no significant change in expression of p53 was observed. -SCBT Publication Review
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