PRIMA-1MET is a methylated derivative of PRIMA-1 (sc-200927). This compound has been shown to restore mutant p53 activity, and to act synergistically with chemotherapeutic agents to inhibit tumor cell proliferation. PRIMA-1MET is an inhibitor of Trx and an activator of p53.
1. Bykov, Vladimir J N., et al., 2005. PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis. Oncogene. 24(21): 3484-91. PMID: 15735745
2. Shen, J., et al., 2008. PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2. Oncogene. 27(51): 6571-80. PMID: 18663359
문의주셔서 감사합니다. 화학품은 측정방법에 따라 분석증명서에 기록된 순도가 lot마다 다를수 있습니다. 구매하신 제품의 lot넘버로 웹사이트에서 분석증명서를 다운로드하세요. 또는 기술지원팀에 연락하셔서 최근 판매한 lot의 순도를 문의하세요, 전화:001 800-1338-3838또는021-60936350 내선번호 529; 이메일: firstname.lastname@example.org 또는 온라인문의로 문의하시면 됩니다.
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot. Please call us directly at (86 21) 6093-6350, email email@example.com, or contact us by live chat.
Rated 5 out of
SobhaniSobhani, M. et al. (PubMed 25803193) evaluated the anti-tumor activity of PRIMA-1MET in Waldenstr m's Macroglobulinemia (WM) cell lines. Treatment with PRIMA-1MET resulted in induction of apoptosis, inhibition of migration and suppression of colony formation. Upon PRIMA-1MET treatment, p73 was upregulated and Bcl-xL was down-regulated while no significant change in expression of p53 was observed. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.