PRIMA-1MET CAS: 5291-32-7
MF: C10H17NO3
MW: 199.25

PRIMA-1MET (CAS 5291-32-7)

PRIMA-1MET | CAS 5291-32-7 is rated 5.0 out of 5 by 1.
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Alternate Names: PRIMA-1MET is also known as APR-246.
Application: PRIMA-1MET is a methylated derivative of PRIMA-1 shown to restore mutant p53 activity and triggers apoptosis in tumor cells.
CAS Number: 5291-32-7
Purity: ≥97%
Molecular Weight: 199.25
Molecular Formula: C10H17NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PRIMA-1MET is a methylated derivative of PRIMA-1 (sc-200927). This compound has been shown to restore mutant p53 activity, and to act synergistically with chemotherapeutic agents to inhibit tumor cell proliferation. PRIMA-1MET also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance. Cellular TrxR1 activity is inhibited by PRIMA-1MET irrespective of p53 status. PRIMA-1MET can directly affect cellular redox status via targeting of TrxR1. PRIMA-1MET has also been shown to reactivate mutant forms of the p63 and p73 proteins that share high structural homology with p53. PRIMA-1MET treatment increases Hsp70 expression and nucleolar translocation, in parallel with the induction of nucleolar accumulation of mutant p53. PRIMA-1MET is also known as APR-246, 2-(hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one, and 2-(hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one.


References

1. Bykov, Vladimir J N., et al., 2005. PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis. Oncogene. 24(21): 3484-91. PMID: 15735745

2. Shen, J., et al., 2008. PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2. Oncogene. 27(51): 6571-80. PMID: 18663359

3. Stuber, György., et al., 2009. PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein. Molecular cancer. 8(): 23. PMID: 19323829

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and DMSO (100 mM).
Storage :
Store at 4° C
Boiling Point :
313.76° C at 760 mmHg (Predicted)
Density :
1.21 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
52918385
MDL Number :
MFCD16294187
SMILES :
COCC1(C(=O)C2CCN1CC2)CO

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Certificate of Analysis

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PRIMA-1MET (CAS 5291-32-7)  Product Citations

See how others have used PRIMA-1MET (CAS 5291-32-7). Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 30895171  Tessoulin, B.|Descamps, G.|Dousset, C.|Amiot, M.|Pellat-Deceunynck, C.| et al. 2019. Front Oncol. 9: 128.

PMID: # 26986846  Yoshikawa, N. et al. 2016. Oncol. Rep. 35: 2543-52.

PMID: # 27533080  Venkatesan, S. et al. 2016. Oncotarget. 7: 58435-58444.

PMID: # 26463477  Grellety, T.|Laroche-Clary, A.|Chaire, V.|Lagarde, P.|Chibon, F.|Neuville, A.|Italiano, A.| et al. 2015. BMC Cancer. 15: 684.

Citations 1 to 4 of 4 total

위 제품의 purity는 어느정도 인가요?

Asked by: Swan
문의주셔서 감사합니다. 화학품은 측정방법에 따라 분석증명서에 기록된 순도가 lot마다 다를수 있습니다. 구매하신 제품의 lot넘버로 웹사이트에서 분석증명서를 다운로드하세요. 또는 기술지원팀에 연락하셔서 최근 판매한 lot의 순도를 문의하세요, 전화:001 800-1338-3838또는021-60936350 내선번호 529; 이메일: [email protected] 또는 온라인문의로 문의하시면 됩니다. Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot. Please call us directly at (86 21) 6093-6350, email [email protected], or contact us by live chat.
Answered by: Technical Support
Date published: 2017-03-21
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Rated 5 out of 5 by from Sobhani Sobhani, M. et al. (PubMed 25803193) evaluated the anti-tumor activity of PRIMA-1MET in Waldenstr m's Macroglobulinemia (WM) cell lines. Treatment with PRIMA-1MET resulted in induction of apoptosis, inhibition of migration and suppression of colony formation. Upon PRIMA-1MET treatment, p73 was upregulated and Bcl-xL was down-regulated while no significant change in expression of p53 was observed. -SCBT Publication Review
Date published: 2015-04-25
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