PRIMA-1A reactivator of p53 and inducer of apoptosis

PRIMA-1 (CAS 5608-24-2)

PRIMA-1 | CAS 5608-24-2 is rated 5.0 out of 5 by 1.
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Synonym: 2,2-bis(Hydroxymethyl)-3-quinuclidinone
Application: A reactivator of p53 and inducer of apoptosis
CAS Number: 5608-24-2
Purity: ≥98%
Molecular Weight: 185.22
Molecular Formula: C9H15NO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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PRIMA-1, named for p53 reactivation and induction of massive apoptosis, is a small molecule identified for its p53 reactivating effect. PRIMA-1 has been shown to restore transcriptional activity and native function to mutant-type p53 systems, which has been directly correlated to reintroduction of p53-dependent apoptosis and destruction of tumor viability.


References

1. Bykov, V.J., et al. 2002. Nat. Med. 8: 282-288. PMID: 11875500
2. Shi, H., et al. 2008. Carcinogenesis. 29: 1428-1434. PMID: 18048389
3. Wang, W., et al. 2008. Curr Opin Oncol. 20: 90-96. PMID: 18043262
4. Magrini, R., et al. 2008. J. Cell. Biochem. 104: 2363-2373. PMID: 18442053

Physical State :
Solid
Solubility :
Soluble in water (20 mg/ml), ethanol (~25 mg/ml), DMSO (~25 mg/ml), DMF (~25 mg/ml), and PBS(PH 7.2) (~2.5 mg/ml).
Storage :
Store at -20° C
Melting Point :
121.75° C (Predicted)
Boiling Point :
~353.7° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.58
pK Values :
pKa: 13.69, pKb: 5.27
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
322968
MDL Number :
MFCD04974196
SMILES :
C1CN2CCC1C(=O)C2(CO)CO

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Certificate of Analysis

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PRIMA-1  Product Citations

See how others have used PRIMA-1. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28792088  Han, Y. et al. 2017. Cell Biol. Int. 41: 1296-1306.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Magrini et al Magrini et al. (Pubmed ID 18442053) showed that PRIMA-1, in addition to adriamycin, induced cell death in non-small cell lung cancer cells by promoting PARP cleavage without DNA fragmentation. -SCBT Publication Review
Date published: 2015-01-15
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