PRIMA-1, named for p53 reactivation and induction of massive apoptosis, is a small molecule identified for its p53 reactivating effect. PRIMA-1 has been shown to restore transcriptional activity and native function to mutant-type p53 systems, which has been directly correlated to reintroduction of p53-dependent apoptosis and destruction of tumor viability.
1. Bykov, V.J., et al. 2002. Nat. Med. 8: 282-288. PMID: 11875500 2. Shi, H., et al. 2008. Carcinogenesis. 29: 1428-1434. PMID: 18048389 3. Wang, W., et al. 2008. Curr Opin Oncol. 20: 90-96. PMID: 18043262 4. Magrini, R., et al. 2008. J. Cell. Biochem. 104: 2363-2373. PMID: 18442053
Soluble in water (20 mg/ml), ethanol (~25 mg/ml), DMSO (~25 mg/ml), DMF (~25 mg/ml), and PBS(PH 7.2) (~2.5 mg/ml).
Store at -20° C
121.75° C (Predicted)
~353.7° C at 760 mmHg (Predicted)
~1.3 g/cm3 (Predicted)
pKa: 13.69, pKb: 5.27
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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PRIMA-1 Product Citations
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Magrini et alMagrini et al. (Pubmed ID 18442053) showed that PRIMA-1, in addition to adriamycin, induced cell death in non-small cell lung cancer cells by promoting PARP cleavage without DNA fragmentation. -SCBT Publication Review
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