Pregnenolone is an endogenous neurosteroid that is involved in the steroidogenesis of progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens, making it a prohormone. It has been observed to inhibit GABA-gated chloride currents by enhancing receptor desensitization. Pregnenolone is an inhibitor of GABA Receptor and an activator of PXR.
Shen W, Mennerick S, Covey DF, Zorumski CF. J Neurosci. 20:3571-9 (2000). Cascio C, Guarneri R, Russo D et al. J Neurochem. 74:2380-91(Grigoryev DN, Long BJ, Njar VC, Brodie AH. J Steroid Biochem Mol Biol. 75:1-10 (2000).