PRE-084 HydrochlorideA high affinity selective sigma 1 agonist

PRE-084 Hydrochloride (CAS 138847-85-5)

PRE-084 Hydrochloride | CAS 138847-85-5 is rated 5.0 out of 5 by 1.
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Application: A high affinity selective sigma 1 agonist
CAS Number: 138847-85-5
Purity: 98%
Molecular Weight: 353.88
Molecular Formula: C19H27NO3·HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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PRE-084 Hydrochloride is a high affinity, selective Sigma Receptor (σ1) agonist (Ki values are 2.2 and 13091 nM for σ1 and σ2 receptors respectively). PRE-084 hydrochloride is selective over PCP receptors (IC50 > 100000 nM) and several other receptor systems.


References

1. Su, T.P., et al. 1991. J. Pharmacol. Exp. Ther. 259: 543-550. 2. Maurice, T., et al. 1999. Br. J. Pharmacol. 127: 335-342. 3. Brown, C., et al. 2004. Br. J. Pharmacol. 141: 233-240.

Physical State :
Solid
Solubility :
Soluble in water (25 mM), and DMSO (75 mM).
Storage :
Store at room temperature
IC50 :
PCP receptors: IC50 = >1000 µM
Ki Data :
σ1 receptors: Ki= 2.2 nM; σ2 receptors: Ki= 13091 nM
pK Values :
pKb: 5.99
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11314197
MDL Number :
MFCD00673883
SMILES :
C1CCC(CC1)(C2=CC=CC=C2)C(=O)OCCN3CCOCC3.Cl

Download SDS (MSDS)

Certificate of Analysis

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PRE-084 Hydrochloride  Product Citations

See how others have used PRE-084 Hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24726897  Sun, B. et al. 2014. Cellular signalling. 26: 1863-9.

Citations 1 to 1 of 1 total

What is the purity?

Asked by: SCM4
This chemical, PRE-084 Hydrochloride (CAS 138847-85-5), typically has a purity of 98%.
Answered by: Chemical Support 1
Date published: 2017-03-24

jag vill köpa pre-084 hydrochloride av er 10 mg

Asked by: jonny
Tack för din fråga. Vi har denna produkten i den storleken. Snälla kontakta vårt Europeiska kontor för information on hur du kan köpa sc-203447, PRE-084 Hydrochloride, 10 mg. Här är vår kontaktinformation: Toll Free: 00800 4573 8000 Phone: +49 (0)6221 4503 0 e-mail: europe@scbt.com Du kan även kontakta vår distributör i Sverige: AH diagnostics AB Phone: 46 (0)8 680 0845 Email: ahdiagnostics@ahdiagnostics.se Website: http://www.ahdiagnostics.se
Answered by: Tech Service
Date published: 2016-10-05
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Rated 5 out of 5 by from Pabba Pabba, M. et al. (PubMed 25143613) reported that NMDA receptors are upregulated and trafficked to the plasma membrane after sigma-1 receptor activation, via PRE-084, in the rat hippocampus. -SCBT Publication Review
Date published: 2015-07-06
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