PQ401

PQ401 (CAS 196868-63-0)

PQ401 | CAS 196868-63-0 is rated 5.0 out of 5 by 1.
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Application: An inhibitor of IGF-1R autophosphorylation
CAS Number: 196868-63-0
Purity: ≥98%
Molecular Weight: 341.8
Molecular Formula: C18H16ClN3O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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PQ401 is a cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation. The mechanism of inhibition likely involves indirect blocking of ATP binding. PQ401 also decreases IGF-1R-dependent tumor cell growth in vitro.


References

Gable, K.L., et al. 2006. Mol. Cancer Ther. 5, 1079.

Physical State :
Solid
Solubility :
Soluble in DMSO or Ethanol
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
9549305
SMILES :
COc1ccc(Cl)cc1NC(=O)Nc1cc(C)nc2ccccc12

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Certificate of Analysis

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Rated 5 out of 5 by from Zhou et al Zhou et al. (PubMed ID 25971682) found that the IGF-1R inhibitor, PQ401, induced apoptosis and blocked growth, proliferation and migration of glioma cells. -SCBT Publication Review
Date published: 2015-01-02
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