Anti-PPARγ2 Antibody (A-1) is a mouse monoclonal IgG2a κ PPARγ2 antibody, cited in 12 publications, provided at 200 µg/ml
specific for an epitope mapping between amino acids 2-20 at the N-terminus of PPARγ2 of human origin
PPAR gamma 2 Antibody (A-1) is recommended for detection of PPARγ2 of human origin by WB, IP, IF, IHC(P) and ELISA; non cross-reactive with PPARγ1
TransCruz reagent for ChIP application (sc-166731 X, 200 µg/0.1 ml)
Anti-PPAR gamma 2 Antibody (A-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of PPARγ2 (A-1): sc-166731.
m-IgG Fc BP-HRP (mouse IgG Fc binding protein-HRP) and m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) are the preferred secondary detection reagents for PPARγ2 Antibody (A-1) for WB and IHC(P) applications. These reagents are now offered in bundles with PPARγ2 Antibody (A-1) (see ordering information below).
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Labware ships FedEx Ground free of charge to the contiguous US
PPARγ2 Antibody (A-1) is a high quality monoclonal PPAR gamma 2 antibody (also designated PPARG2 antibody) suitable for the detection of the PPAR gamma 2 protein of human origin. PPARγ2 Antibody (A-1) is available as both the non-conjugated anti-PPAR gamma 2 antibody form, as well as multiple conjugated forms of anti-PPAR gamma 2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor subfamily of transcription factors. PPARs form heterodimers with retinoid X receptors (RXRs). These heterodimers regulate transcription of genes involved in insulin action, adipocyte differentiation, lipid metabolism and inflammation. PPARγ is implicated in numerous diseases including obesity, diabetes, atherosclerosis and cancer. PPARγ activators include prostanoids, fatty acids, thiazolidinediones and N-(2-benzoylphenyl) tyrosine analogues. A key component in adipocyte differentiation and fat-specific gene expression, PPARγ may modulate macrophage functions such as proinflammatory activities, and stimulate oxidized low-density lipoprotein (x-LDL) uptake. A Pro12Ala polymorphism of the PPARγ2 gene has been reported to reduce transactivation activity in vitro. This substitution may affect the immune response to ox-LDL and be associated with type 2 diabetes. In addition, the Pro12Ala variant of the PPARγ2 gene maybe correlated with abdominal obesity in type 2 diabetes.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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