PPARγ Antagonist III, G3335 is a cell-permeable dipeptide that acts as a selective and reversible PPAR γ antagonist (KD ~ 8 μM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner (IC50 = 31.9 µM) in transfected COS-7 cells.
1. Ye, F., et al. 2006. Chembiochem. 7: 74-82. PMID: 16317783 2. Ho, T.C. et al. 2008. J. Biol. Chem. 283(44): 30273-30288. PMID: 18718914
Soluble in water (30 mg/ml).Addition of a small amount of acid or base may be required for complete solubilization.
Store at 4° C
328.90° C (Predicted)
720.69° C at 760 mmHg (Predicted)
1.43 g/cm3 (Predicted)
n20D 1.66 (Predicted)
α20/D +34.8°, c = 1 in water
agonist activity of Rosiglitazone: IC50 = 31.9 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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PPARγ Antagonist III, G3335 Product Citations
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HoHo, TC. et al. (PubMed 18718914) used G3335, a dipeptide that acts as a selective PPAR antagonist, to find that p53 protein accumulation and apoptosis induced by 15d-PGJ2 are independent of PPAR activation. -SCBT Publication Review
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