PPARγ Antagonist III, G3335A cell-permeable dipeptide that acts as a selective PPAR-γ antagonist

PPARγ Antagonist III, G3335 (CAS 36099-95-3)

PPARγ Antagonist III, G3335 | CAS 36099-95-3 is rated 5.0 out of 5 by 1.
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Application: A cell-permeable dipeptide that acts as a selective PPAR-γ antagonist
CAS Number: 36099-95-3
Purity: >97%
Molecular Weight: 333.3
Molecular Formula: C16H19N3O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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PPARγ Antagonist III, G3335 is a cell-permeable dipeptide that acts as a selective and reversible PPAR γ antagonist (KD ~ 8 μM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner (IC50 = 31.9 µM) in transfected COS-7 cells.


References

1. Ye, F., et al. 2006. Chembiochem. 7: 74-82. PMID: 16317783
2. Ho, T.C. et al. 2008. J. Biol. Chem. 283(44): 30273-30288. PMID: 18718914

Physical State :
Solid
Solubility :
Soluble in water (30 mg/ml).Addition of a small amount of acid or base may be required for complete solubilization.
Storage :
Store at 4° C
Melting Point :
328.90° C (Predicted)
Boiling Point :
720.69° C at 760 mmHg (Predicted)
Density :
1.43 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
Optical Activity :
α20/D +34.8°, c = 1 in water
IC50 :
agonist activity of Rosiglitazone: IC50 = 31.9 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3634442
MDL Number :
MFCD00037964
SMILES :
C1=CC=C2C(=C1)C(=CN2)CC(C(=O)NC(CCC(=O)O)C(=O)O)N

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Certificate of Analysis

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PPARγ Antagonist III, G3335  Product Citations

See how others have used PPARγ Antagonist III, G3335. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 18718914  Ho, TC. et al. 2008. J. Biol. Chem. 283: 30273-30288.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Ho Ho, TC. et al. (PubMed 18718914) used G3335, a dipeptide that acts as a selective PPAR antagonist, to find that p53 protein accumulation and apoptosis induced by 15d-PGJ2 are independent of PPAR activation. -SCBT Publication Review
Date published: 2015-01-12
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