PPAHVNon-pungent resiniferatoxin-type phorboid vanilloid and agonist

PPAHV (CAS 175796-50-6)

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Synonym: Phorbol 12-phenylacetate 13-acetate 20-homovanillate
Application: Non-pungent resiniferatoxin-type phorboid vanilloid and agonist
CAS Number: 175796-50-6
Purity: >99%
Molecular Weight: 688.8
Molecular Formula: C39H44O11
* Refer to Certificate of Analysis for lot specific data (including water content).
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PPAHV is a non-pungent resiniferatoxin-type phorboid vanilloid. Agonist at rat VR1(TRPV1) (EC50 between 3 and 10 μM) but virtually inactive at human VR1(TRPV1) (EC50>10 μM). PPAHV additionally induces apoptosis through a TRPV-independent mechanism and is a tumor promotor.


References

1. Appendino, G., et al. 1996. J. Med. Chem. 39: 3123-3131. PMID: 8759633
2. Szallasi, A., et al. 1996. Eur. J. Pharmacol. 299: 221-228. PMID: 8901026
3. Liu, L., et al. 1999. Neuroscience. 84: 569-581. PMID: 9539227
4. Griffiths, C.D., et al. 2000. Br. J. Pharmacol. 131: 1408-1412. PMID: 11090114

Physical State :
Solid
Solubility :
Soluble in DMSO, methanol, and 100% ethanol. Insoluble in water.
Storage :
Store at 4° C
Boiling Point :
792.42° C at 760 mmHg (Predicted)
Density :
1.36 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
TRPV1: EC5050 = 3-10 µM (rat)
Ki Data :
Vanilloid receptor: Ki= 0.05 nM (rat); VR: Ki= 0.12 nM (human); vanilloid TRPV1 (VR1) receptor: Ki= 3.1 µM
pK Values :
pKa: 9.85 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
3035862
MDL Number :
MFCD06411584
SMILES :
[H][C@]1([C@@]2(C3[C@@](C(=O)C(=C3)C)(CC(=C[C@H]2C4C([C@@]4([C@@H]1OC(=O)CC5=CC=CC=C5)OC(=O)C)(C)C)COC(=O)CC6=CC(=C(C=C6)O)OC)O)O)[H]

Download SDS (MSDS)

Certificate of Analysis

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