PPAHV is a non-pungent resiniferatoxin-type phorboid vanilloid. Agonist at rat VR1(TRPV1) (EC50 between 3 and 10 μM) but virtually inactive at human VR1(TRPV1) (EC50>10 μM). PPAHV additionally induces apoptosis through a TRPV-independent mechanism and is a tumor promotor.
1. Appendino, G., et al. 1996. J. Med. Chem. 39: 3123-3131. PMID: 8759633 2. Szallasi, A., et al. 1996. Eur. J. Pharmacol. 299: 221-228. PMID: 8901026 3. Liu, L., et al. 1999. Neuroscience. 84: 569-581. PMID: 9539227 4. Griffiths, C.D., et al. 2000. Br. J. Pharmacol. 131: 1408-1412. PMID: 11090114
Soluble in DMSO, methanol, and 100% ethanol. Insoluble in water.
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