PPACK dihydrochloride CAS: 142036-63-3
MF: C21H31ClN6O3•2HCl
MW: 523.88

PPACK dihydrochloride (CAS 142036-63-3)

PPACK dihydrochloride | CAS 142036-63-3 is rated 5.0 out of 5 by 3.
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Alternate Names: PPACK dihydrochloride is also known as D-Phe-Pro-Arg-CMK.
Application: PPACK dihydrochloride is an irreversible, potent, selective inhibitor of thrombin and its downstream effects.
CAS Number: 142036-63-3
Molecular Weight: 523.88
Molecular Formula: C21H31ClN6O32HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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PPACK dihydrochloride is known to be an irreversible and potent inhibitor of thrombin. PPACK dihydrochloride is shown to inhibit thrombin activation of progelatinase A. In vivo pretreatment with PPACK dihydrochloride has been shown to inhibit thrombin-induced cerebral thromboembolism. PPACK dihydrochloride is also known to act as an anticoagulant in platelet-rich plasma. PPACK dihydrochloride is also known as D-Phenylalanyl-prolyl-arginyl Chloromethyl Ketone, D-Phe-Pro-Arg-CMK, and D-Phe-Pro-Arg-chloromethylketone.


References

1. Liu, J.T. 1994. Eur. J. Pharmacol. 264(2): 183-190. PMID: 7851481 2. Rahr, H.B. 1994. Thromb. Res. 73(5): 279-284. PMID: 8016814 3. Zucker, S. 1995. J. Biol. Chem. 270(40): 23730-23738. PMID: 7559545 4. Kereiakes, D.J. 2001. J. Thromb. Thrombolysis. 12

Physical State :
Solid
Sequence :
D-Phe-Pro-Arg-chloromethylketone
Solubility :
Soluble in water (0.3 mg/ml at 25° C).
Storage :
Store at -20° C
Refractive Index :
n20D 1.64
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
C1C[[email protected]](N(C1)C(=O)[[email protected]@H](CC2=CC=CC=C2)N)C(=O)N[[email protected]@H](CCCN=C(N)N)C(=O)CCl.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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PPACK dihydrochloride (CAS 142036-63-3)  Product Citations

See how others have used PPACK dihydrochloride (CAS 142036-63-3). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 21 total

PMID: # 34122402  Garishah, FM.|Rother, N.|Riswari, SF.|Alisjahbana, B.|Overheul, GJ.|van Rij, RP.|van der Ven, A.|van der Vlag, J.|de Mast, Q.| et al. 2021. Front Immunol. 12: 629167.

PMID: # 30722079  Yu, X. et al. 2019. Thromb. Haemost. 119: 586-593.

PMID: # 31423724  Ferrière, S.|Kawecki, C.|Ottavi, JF.|Denis, CV.|Kauskot, A.|Christophe, OD.|Lenting, PJ.| et al. 2019. J Thromb Haemost. 17: 2035-2046.

PMID: # 30560697  Rigg, RA. et al. 2019. Platelets. 30: 126-135.

PMID: # 30460241  Tullemans, BME. et al. 2018. Front Cardiovasc Med. 5: 142.

PMID: # 29785664  Zilberman-Rudenko, J.|Zhao, FZ.|Reitsma, SE.|Mitrugno, A.|Pang, J.|Shatzel, JJ.|Rick, B.|Tyrrell, C.|Hasan, W.|McCarty, OJT.|Schreiber, MA.| et al. 2018. Cardiovasc Eng Technol. 9: 515-527.

PMID: # 28083075  Zilberman-Rudenko, J.|Itakura, A.|Maddala, J.|Baker-Groberg, SM.|Vetter, R.|Tucker, EI.|Gruber, A.|Gerdes, C.|McCarty, OJ.| et al. 2016. Cell Mol Bioeng. 9: 496-508.

PMID: # 26725377  Zhu, S. et al. 2016. J. Thromb. Haemost. 14: 1070-81.

PMID: # 27816455  Streng, AS. et al. 2016. Biochem. Biophys. Res. Commun. 481: 165-168.

PMID: # 25418346  Jiménez-Alcázar, M. et al. 2015. J. Thromb. Haemost. 13: 732-42.

Citations 1 to 10 of 21 total

What is the shipping temperature for this product?

Asked by: hawkeye11
This chemical, PPACK dihydrochloride (CAS 71142-71-7), ships on blue ice.
Answered by: Chemical Support 1
Date published: 2017-03-22
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Rated 5 out of 5 by from Great thrombin inhibitor We have been using PPACK from Santa Cruz for many years and it works very well.
Date published: 2020-01-24
Rated 5 out of 5 by from PPACK We used this thrombin inhibitor from Santa Cruz Biotechnology. It works well.
Date published: 2019-11-21
Rated 5 out of 5 by from Worked well for our lab Worked well for our lab.
Date published: 2015-06-10
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