PP242 CAS: 1092351-67-1
MF: C16H16N6O
MW: 308.34
PP242 is a selective FRAP inhibitor.

PP242 (CAS 1092351-67-1)

PP242 | CAS 1092351-67-1 is rated 5.0 out of 5 by 1.
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Alternate Names: 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol
Application: PP242 is a selective FRAP inhibitor
CAS Number: 1092351-67-1
Purity: ≥98%
Molecular Weight: 308.34
Molecular Formula: C16H16N6O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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PP242 has been shown to be a an ATP-competitive FRAP (mTORC1/mTORC2) inhibitor (IC50 = 8 nM). PP242 is the first selective inhibitor that targets the ATP domain of FRAP. This compound shows selectivity for FRAP over other PI 3-kinase (PI 3K family kinases) (IC50 values are 0.102, 0.408, 1.27, 1.96 and 2.2 μM for p110γ, DNA-PK, PI 3-kinase p110δp110δ, p110α and p110β respectively). Furthermore, PP242 hydrate inhibits both S6K and 4EBP1 phosphorylation this activity displays an overall decrease in cap-dependent protein translation. PP242 hydrate is an inhibitor of JAK2 and PKC α. PP242 hydrate is an inhibitor of JAK2, PKC alpha, PKC beta and Ret.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (>10 mg/ml), ethanol (0.5 mg/ml), DMF (20 mg/ml), 1:1 solution of DMF: PBS(pH 7.2) (0.5 mg/ml), and water (<1 mg/ml).
Storage :
Store at 4° C
Boiling Point :
~642° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.80 (Predicted)
pK Values :
pKa: 9.51 (Predicted), pKb: 4.38 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
PubChem CID :
MDL Number :
MFCD12828866
SMILES :
CC(C)N1C2=NC=NC(=C2/C(=C\\3/C=C4C=C(C=CC4=N3)O)/N1)N

Download SDS (MSDS)

Certificate of Analysis

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PP242 (CAS 1092351-67-1)  Product Citations

See how others have used PP242 (CAS 1092351-67-1). Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 30244168  Dong, X. et al. 2019. Cellular signalling. 53: 68-79.

PMID: # 28300280  Zeng, Q. et al. 2018. Journal of cellular physiology. 233: 516-529.

PMID: # 28106723  Zhang, C.|Yan, J.|Xiao, Y.|Shen, Y.|Wang, J.|Ge, W.|Chen, Y.| et al. 2017. Int J Mol Sci. 18:

PMID: # 25616664  Nighot, PK. et al. 2015. J. Biol. Chem. 290: 7234-46.

PMID: # 23459592  Read, RD. et al. 2013. PLoS Genet. 9: e1003253.

PMID: # 32062191  Cell calcium. 87: 102171.

Citations 1 to 6 of 6 total
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Rated 5 out of 5 by from Bao Y; et al Bao Y; et al. (PubMed ID: 26416965) utilized PP242 to block mTOR signaling in neutrophils. -SCBT Publication Review
Date published: 2015-04-20
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