PP 3A negative control for the Src family protein tyrosine kinase inhibitor PP2

PP 3 (CAS 5334-30-5)

PP 3 | CAS 5334-30-5 is rated 5.0 out of 5 by 1.
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Synonym: 4-Amino-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine
Application: A negative control for the Src family protein tyrosine kinase inhibitor PP2
CAS Number: 5334-30-5
Purity: ≥97%
Molecular Weight: 211.23
Molecular Formula: C11H9N5
* Refer to Certificate of Analysis for lot specific data (including water content).
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PP 3 is a negative control for the Src family protein tyrosine kinase inhibitor PP2. However, it inhibits the activity of EGFR kinase (IC50 = 2.7 μM).


References

Traxler, P., et al. 1997. J. Med. Chem. 40, 3601.

Physical State :
Solid
Solubility :
Soluble in water, DMSO (100 mM), methanol (easily), ethanol (25 mM), and DMF.
Storage :
Store at room temperature
Melting Point :
214-217° C
Boiling Point :
~364.0° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.77 (Predicted)
IC50 :
the activity of EGFR kinase: IC50 = 2.7 µM; Phosphatidylinositol 4-kinase: IC50 = 16.1 µM (human)
Ki Data :
Phosphatidylinositol 4-kinase: Ki= 11 µM (human)
pK Values :
pKb: 3.93 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
4879
MDL Number :
MFCD00022901
Beilstein Registry :
198460
SMILES :
NC1=C2C=NN(C2=NC=N1)C1=CC=CC=C1

Download SDS (MSDS)

Certificate of Analysis

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PP 3  Product Citations

See how others have used PP 3. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26578881  De Mario, A. et al. 2015. Frontiers in cellular neuroscience. 9: 416.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Various publications cite the use of PP 3 Various publications cite the use of PP 3 as a negative control for the Src family protein tyrosine kinase inhibitor PP2. -SCBT Publication Review
Date published: 2015-05-09
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