Ponasterone AA member of the ecdysteroid family with similar properties to muristerone A

Ponasterone A (CAS 13408-56-5)

Ponasterone A | CAS 13408-56-5 is rated 5.0 out of 5 by 1.
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Synonym: 25-Deoxyecdysterone
Application: A member of the ecdysteroid family with similar properties to muristerone A
CAS Number: 13408-56-5
Purity: >95%
Molecular Weight: 464.64
Molecular Formula: C27H44O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ponasterone A is an analog of ecdysone A and a member of the ecdysteroid family with similar properties to muristerone A. It is a functional, reliable and economical substitute for muristerone A as an inducer for the ecdysone-inducible mammalian expression system. Ponasterone A is an insect hormone involved in regulating metamorphosis.


References

1. Beckers, C., 1980. Mol. Cell. Endocrinol. 17: 51-59. PMID: 6244205
2. Nakanishi, K. 1992. Steroids. 57: 649-657. PMID: 1481229
3. Albanese, C., et al. 2000. FASEB J. 14: 877-884. PMID: 10783141
4. Saez, E., et al. 2000. Proc. Natl. Acad. Sci. U.S.A. 97: 14512-14517. PMID: 11114195
5. Albanese, C., et al. 2002. Semin. Cell Dev. Biol. 13: 129-141. PMID: 12240598
6. Xiao, Y.Y., et al. 2003. Int. J. Biochem. Cell Biol. 35: 79-85. PMID: 12467649

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in ethanol, methanol, DMSO, and HOAc. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
255.76° C (Predicted)
Boiling Point :
640.51° C at 760 mmHg (Predicted)
Density :
1.23 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
Ecdysone receptor: IC50 = 1.29 nM (Drosophila melanogaster); Ecdysone receptor: IC50 = 900 nM (Lucilia cuprina)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
115127
Merck Index :
14: 7588
MDL Number :
MFCD00272144
Beilstein Registry :
2422988
SMILES :
CC(C)CC[C@H]([C@@](C)([C@H]1CC[C@@]2([C@@]1(CC[C@H]3C2=CC(=O)[C@H]4[C@@]3(C[C@@H]([C@@H](C4)O)O)C)C)O)O)O

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Certificate of Analysis

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Ponasterone A  Product Citations

See how others have used Ponasterone A. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 28174130  Honda, Y. et al. 2017. Gen. Comp. Endocrinol. 247: 183-198.

PMID: # 28043811  Zhou, B. et al. 2017. Biochem. Pharmacol. 128: 12-25.

PMID: # 26898150  Venne, P. et al. 2016. J Chromatogr A. 1438: 57-64.

PMID: # 25656655  Varadarajan, S. et al. 2015. Cell Death Differ. 22: 1388-96.

PMID: # 26100538  Tan, Z. et al. 2015. Molecular psychiatry. 20: 1286-93.

PMID: # 24121255  Kloster, E. et al. 2014. J. Mol. Med. 92: 177-84.

Citations 1 to 6 of 6 total
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Rated 5 out of 5 by from Saez et al Saez et al. (PubMed ID 11114195) used ponasterone A to regulate gene expression in cells and transgenic animals. -SCBT Publication Review
Date published: 2015-03-17
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