Polyinosinic-polycytidylic acid potassium salt is an activator of Toll-like receptor 3 (TLR3) and MDA5/Helicard. This double-stranded homopolymer provides a useful model RNA to study cell signaling at the level of TLR3, a modulator of the immune response to viral pathogens.
 The dsRNA binding site of human Toll-like receptor 3: J.K. Bell, et al.; PNAS 103, 8792 (2006)  Subcellular localization of Toll-like receptor 3 in human dendritic cells: M. Matsumoto, et al.; J. Immunol. 171, 3154 (2003)  Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses: H. Kato, et al.; Nature 441, 101 (2006)
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.