Polyinosinic-polycytidylic acid potassium saltCAS: 31852-29-6
A specific ligand for TLR3 and MDA5/Helicard.

Polyinosinic-polycytidylic acid potassium salt (CAS 31852-29-6)

Polyinosinic-polycytidylic acid potassium salt | CAS 31852-29-6 is rated 5.0 out of 5 by 1.
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Application: A specific ligand for TLR3 and MDA5/Helicard
CAS Number: 31852-29-6
* Refer to Certificate of Analysis for lot specific data (including water content).

Polyinosinic-polycytidylic acid potassium salt is an activator of Toll-like receptor 3 (TLR3) and MDA5/Helicard. This double-stranded homopolymer provides a useful model RNA to study cell signaling at the level of TLR3, a modulator of the immune response to viral pathogens.


References

[1] The dsRNA binding site of human Toll-like receptor 3: J.K. Bell, et al.; PNAS 103, 8792 (2006) [2] Subcellular localization of Toll-like receptor 3 in human dendritic cells: M. Matsumoto, et al.; J. Immunol. 171, 3154 (2003) [3] Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses: H. Kato, et al.; Nature 441, 101 (2006)

Appearance :
Lyophilized powder
Physical State :
Solid
Derived From :
Non-native source. Synthetic.
Solubility :
Soluble in water (10 mg/ml).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
MDL Number :
MFCD00131983

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Duchatel Duchatel, RJ. et al. (PubMed 26385575) induced maternal immune activation, a risk factor for schizophrenia, by injecting pregnant rats with Polyinosinic-polycytidylic acid, a specific ligand for TLR3 and MDA5/Helicard. -SCBT Publication Review
Date published: 2015-04-13
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