Polyglutamine Aggregation Inhibitor, PGL-135A benzothiazole polyQ-aggregation inhibitor

Polyglutamine Aggregation Inhibitor, PGL-135 (CAS 26278-83-1)

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Synonym: (2-Amino-4,7-dimethyl)benzothiazol-6-ol, HCl; (2-Amino-4,7-dimethyl-6-hydroxy)benzothiazole, HCl
Application: A benzothiazole polyQ-aggregation inhibitor
CAS Number: 26278-83-1
Molecular Weight: 230.7
Molecular Formula: C9H10N2OS•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Polyglutamine Aggregation Inhibitor, PGL-135 is a cell-permeable benzothiazole compound that binds to polyglutamine (PQBP-1, polyQ)-containing β-sheet structures and prevents polyQ-aggregation, a pathological hallmark of Huntington's disease (HD) and related glutamine repeat disorders. Shown to be non-toxic and prevent HDQ51 (FLAG®-tag HD exon 1 protein with 51 glutamines)-aggregation in 293 Tet-Off (293 tetracycline-off) cells with an IC50 of ~ 40 λµM.


References

1. Heiser, V., et al. 2002. Proc. Natl. Acad. Sci. U.S.A. 99: 16400-16406. PMID: 12200548

Physical State :
Solid
Solubility :
DMSO
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16078999
SMILES :
CC1=CC(=C(C2=C1N=C(S2)N)C)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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