PNU-74654An inhibitor of Wnt/beta-catenin pathway

PNU-74654 (CAS 113906-27-7)

PNU-74654 | CAS 113906-27-7 is rated 5.0 out of 5 by 2.
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Synonym: 2-Phenoxybenzoic acid [(5-methyl-2-furanyl)methylene]hydrazide
Application: An inhibitor of Wnt/beta-catenin pathway
CAS Number: 113906-27-7
Molecular Weight: 320.34
Molecular Formula: C19H16N2O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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PNU-74654 inhibits the Wnt/ beta-catenin pathway by blocking the interaction between beta-catenin and TCF (T cell factor). PNU-74654 is also an anti-tumor agent.


References

1. Barker, N. and Clevers, H. 2006. Nat Rev Drug Discov. 5(12): 997-1014. PMID: 17139285
2. Trosset, J.Y. et al. 2006. Proteins. 64(1): 60-67. PMID: 16568448
3. Wells, J.A. and McClendon, C.L. 2007. Nature. 450(7172): 1001-1009. PMID: 18075579

Physical State :
Solid
Solubility :
Soluble in DMSO: >10 mg/mL
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
60119583
SMILES :
CC1=CC=C(O1)C=NNC(=O)C2=CC=CC=C2OC3=CC=CC=C3

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PNU-74654  Product Citations

See how others have used PNU-74654. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 27546592  Hassanian, SM. et al. 2016. J. Thromb. Haemost. 14: 2261-2273.

PMID: # 25746333  Hao, HP. et al. 2015. Antiviral Res. 117: 99-109.

PMID: # 25882849  Kim, WJ. et al. 2015. The Journal of biological chemistry. 290: 14381-90.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Use it routinely in our lab and works well Use it routinely in our lab and works well.
Date published: 2015-06-10
Rated 5 out of 5 by from Pradhan A; et al Pradhan A; et al. (PubMed ID: 24920039) confirmed that PNU-74654, a -catenin inhibitor, caused up-regulation of ptgds and male-biased sex ratios, thus confirming the participation of -catenin in the female differentiation pathway. -SCBT Publication Review
Date published: 2015-06-10
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