PNU 142633 CAS: 187665-65-2
MF: C24H30N4O3
MW: 422.53
A high affinity SR-1D agonist.

PNU 142633 (CAS 187665-65-2)

PNU 142633 | CAS 187665-65-2 is rated 5.0 out of 5 by 1.
  • y_2021, m_7, d_27, h_19
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.18
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_204204, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 110ms
  • REVIEWS, PRODUCT
loading
5
1
4
0
3
0
2
0
1
0
Alternate Names: (1S)-1-[2-[4-[4-(Aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-1H-2-benzopyran-6-carboxamide
Application: PNU 142633 is a high affinity SR-1D agonist
CAS Number: 187665-65-2
Molecular Weight: 422.53
Molecular Formula: C24H30N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
loading

PNU 142633 is a very selective, high affinity SR-1D agonist (Ki values are 6 and > 18000 nM at human SR-1D and SR-1B, respectively). PNU 142633 blocks neurogenic plasma protein extravasation and inhibits sympathetically-induced tachycardic responses in vivo.


References

Roon et al (1999) Bovine isolated middle cerebral artery contractions to antimigraine drugs. Naunyn-Schmied.Arch.Pharmacol. 360 591. McCall et al (2002) Preclinical studies characterizing the anti-migraine and cardiovascular effects of the selective 5-HT1D receptor agonist PNU-142633. Cephalalgia 22 799. Sanchez-Lopez et al (2003) Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator sympathetic outflow in pithed rats: correlation with 5-HT1 and putative 5-ht5A/5B receptors. Br.J.Pharmacol. 140 725.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (20 mM).
Storage :
Store at 4° C
Melting Point :
287.06° C (Predicted)
Boiling Point :
~652.5° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
Ki Data :
SR-1D: Ki= 4.6 nM (human)
pK Values :
pKb: 7.27 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD10687093
SMILES :
CNC(=O)C1=CC2=C(C=C1)[[email protected]@H](OCC2)CCN3CCN(CC3)C4=CC=C(C=C4)C(=O)N

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 100ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from McCall et al McCall et al. (PubMed ID 12485205) found that PNU 142633, a highly selective 5-HT1D receptor agonist, blocked plasma protein extravasation and reduced the increase in cat nucleus trigeminal caudalis blood flow caused by electrical stimulation of the trigeminal ganglion. -SCBT Publication Review
Date published: 2015-07-02
  • y_2021, m_7, d_27, h_19
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.18
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_204204, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 23ms
  • REVIEWS, PRODUCT