PNU 112455A hydrochlorideAn ATP-competitive inhibitor of CDK2/cyclin E and CDK5/p25

PNU 112455A hydrochloride (CAS 21886-12-4)

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Synonym: Cdk2/5 Inhibitor
Application: An ATP-competitive inhibitor of CDK2/cyclin E and CDK5/p25
CAS Number: 21886-12-4
Purity: ≥95%
Molecular Weight: 301.76
Molecular Formula: C10H11N5O2S•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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PNU 112455A hydrochloride is a selective and ATP-competitive inhibitor of CDK2/cyclin E (Ki = 2 μM) and CDK5/p35 (p25) (Ki = 2 μM). It binds to the ATP-binding pocket of CDK2 and does not affect the activities of c-met, IGF-1 receptor tyrosine kinase, cAMP-dependent kinase and ERK2 at concentrations as high as 100 μM.


References

P.M. Clare, et al.; J. Biol. Chem. 276, 48292 (2001).

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml,clear solution), and water.
Storage :
Store at -20° C
Melting Point :
293-295° C
Boiling Point :
578.9° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.70 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16760362
MDL Number :
MFCD00023272
SMILES :
C1=CC(=CC=C1NC2=NC=NC(=C2)N)S(=O)(=O)N.Cl

Download SDS (MSDS)

Certificate of Analysis

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