PMAA reversible and highly potent protein kinase C (PKC) activator

PMA (CAS 16561-29-8)

PMA | CAS 16561-29-8 is rated 4.8 out of 5 by 6.
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Synonym: Phorbol-12-Myristate-13-Acetate; 12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate
Application: A reversible and highly potent protein kinase C (PKC) activator
CAS Number: 16561-29-8
Purity: ≥95%
Molecular Weight: 616.83
Molecular Formula: C36H56O8
* Refer to Certificate of Analysis for lot specific data (including water content).
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PMA (Phorbol-12-Myristate-13-Acetate) is a diester of phorbol and is a tumor promoting compound extracted from croton oil. It is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations. PMA′s effects on PKC are attributed to its similarity to diacylgylerol, a natural activator of PKC. PMA activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.


1. Castagna, M., et al. 1982. J. Biol. Chem. 257: 7847-7851. PMID: 7085651

2. Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. U.S.A. 82: 2774-2778. PMID: 2859591

3. Saltis, J., et al. 1991. J. Biol. Chem. 266: 261-267. PMID: 1985898

4. Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73: 2011-2015. PMID: 1474079

5. Oishi, K. and Yamaguchi, M. 1994. J. Cell. Biochem. 55: 168-172. PMID: 8089192

6. Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. U.S.A. 92: 8443-8447. PMID: 7545303

7. Powell, D.J., et al. 2003. Mol. Cell. Biol. 23: 7794-7808. PMID: 14560023

8. Saraiva, L., et al. 2004. Eur. J. Pharmacol. 491: 101-110. PMID: 15140626

9. Shimura, C., et al. 2010. Am. J. Pathol. 176: 227-237. PMID: 20008150

Usage :
Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month.
Physical State :
Solubility :
Soluble in DMSO (25 mg/ml), 100%ethanol (25 mg/ml), acetone, ether, DMF, methanol, and chloroform. Insoluble in water, and aqueous buffers.
Storage :
Store at -20° C
Melting Point :
50-70° C
Boiling Point :
~698.10° C at 760 mmHg (Predicted)
Density :
1.17 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
Optical Activity :
α24/D +49°, c = 1 in dioxane
Ki Data :
PKC: Ki= 2.6 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 7332
MDL Number :
Beilstein Registry :

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PMA  Product Citations

See how others have used PMA. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 50 total

PMID: # 30463939  Jeong, J.|Choi, J.|Kim, W.|Dann, P.|Takyar, F.|Gefter, JV.|Friedman, PA.|Wysolmerski, JJ.| et al. 2019. J. Biol. Chem. 294: 887-901.

PMID: # 31427899  Del Mar Díaz-González, S.|Rodríguez-Aguilar, ED.|Meneses-Acosta, A.|Valadez-Graham, V.|Deas, J.|Gómez-Cerón, C.|Tavira-Montalván, CA.|Arizmendi-Heras, A.|Ramírez-Bello, J.|Zurita-Ortega, ME.|Illades-Aguiar, B.|Leyva-Vázquez, MA.|Fernández-Tilapa, G.|Bermúdez-Morales, VH.|Madrid-Marina, V.|Rodríguez-Dorantes, M.|Pérez-Plasencia, C.|Peralta-Zaragoza, O.| et al. 2019. Cancer Cell Int. 19: 214.

PMID: # 31442299  2019. J. Neurochem.

PMID: # 31145102  Halkias, J.|Rackaityte, E.|Hillman, SL.|Aran, D.|Mendoza, VF.|Marshall, LR.|MacKenzie, TC.|Burt, TD.| et al. 2019. J. Clin. Invest. 130:

PMID: # 30005620  Stedman, A.|Maluquer de Motes, C.|Lesellier, S.|Dalley, D.|Chambers, M.|Gutierrez-Merino, J.| et al. 2018. BMC Microbiol. 18: 74.

PMID: # 29374149  Zhao, H.|Zhao, Y.|Li, Z.|Ouyang, Q.|Sun, Y.|Zhou, D.|Xie, P.|Zeng, S.|Dong, L.|Wen, H.|Lu, G.|Lin, G.|Hu, L.| et al. 2018. Cell Death Dis. 9: 131.

PMID: # 29415896  Oshima, M. et al. 2018. JCI Insight. 3:

PMID: # 30502458  Regdon, Z. et al. 2018. Free radical biology & medicine. 131: 184-196.

PMID: # 29491158  Georgana, I.|Sumner, RP.|Towers, GJ.|Maluquer de Motes, C.| et al. 2018. J. Virol. 92:

PMID: # 27816504  Chang, KH.|Park, JM.|Lee, CH.|Kim, B.|Choi, KC.|Choi, SJ.|Lee, K.|Lee, MY.| et al. 2017. Toxicol In Vitro. 38: 49-58.

Citations 1 to 10 of 50 total
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Rated 5 out of 5 by from work well Using PMA from Santa to active neutrophils to NETosis and it works well as the same product from Sigma
Date published: 2018-01-15
Rated 5 out of 5 by from Great PKC activator Ised this PKC activator many times with great results.
Date published: 2017-07-05
Rated 5 out of 5 by from well done We had used PMA for a long time(final conentration 10nmol-100nmol), PMA-treated THP-1 cells grew well and stable, and Western blot worked well too!
Date published: 2016-11-01
Rated 4 out of 5 by from thp-1 differentiate into macrophages thp-1 cells can differentiate into macrophages by using PMA.
Date published: 2016-11-01
Rated 5 out of 5 by from An increase in c An increase in c-Fos protein expression was observed (nuclear extracts) by WB in Jurkat cells post treatment with PMA. Other proteins affected by treatment with PMA include: p-PKC , caspase-6, p63 . -SCBT QC
Date published: 2015-02-01
Rated 5 out of 5 by from Zhou et Zhou et. al. (PubMed ID 23174781) used PMA to mimic Resistin to activate NF- B (via PKC - PKG signal transduction pathway). -SCBT QC
Date published: 2015-02-01
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