(+/-)-threo-3-Methylglutamic acidA glutamate transport blocker selective for EAAT2 and EAAT4

(±)-threo-3-Methylglutamic acid (CAS 63088-04-0)

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Synonym: (2R,3S)-2-amino-3-methylpentanedioic acid; T3MG; threo-3-Methylglutamate
Application: A glutamate transport blocker selective for EAAT2 and EAAT4
CAS Number: 63088-04-0
Molecular Weight: 161.16
Molecular Formula: C6H11NO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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(±)-threo-3-Methylglutamic acid is a potent blocker of glutamate transport. (±)-threo-3-Methylglutamic acid is selective for EAAT2 and EAAT4 (IC50 values are 90, 109, 1600 and 1080 μM for EAAT2, EAAT4, EAAT1 and EAAT3 respectively).


References

Vandenberg et al (1997) Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2. Mol.Pharmacol. 51 809. Mitrovic et al (1998) Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2. J.Biol.Chem. 273 14698. Eliasof et al (2001) Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems. J.Neurochem. 77 550.

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in 1eq. NaOH (100 mM), and water (>1.5 mg/dL).
Storage :
Store at room temperature
Melting Point :
226.22° C (Predicted)
Boiling Point :
329.35° C at 760 mmHg (Predicted)
Density :
1.33 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
IC50 :
EAAT2: IC50 = 90 µM; EAAT4: IC50 = 109 µM; EAAT3: IC50 = 1080 µM; EAAT1: IC50 = 1600 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6604760
MDL Number :
MFCD09836097
SMILES :
CC(CC(=O)O)C(C(=O)O)N

Download SDS (MSDS)

Certificate of Analysis

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