(±)-SulfinpyrazoneA free radical scavenger that inhibits organic anion transporters

(±)-Sulfinpyrazone (CAS 57-96-5)

(±)-Sulfinpyrazone | CAS 57-96-5 is rated 5.0 out of 5 by 1.
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Synonym: 1,2-Diphenyl-4-(phenylsulfinylethyl)-3,5-pyrazolidinedione
Application: A free radical scavenger that inhibits organic anion transporters
CAS Number: 57-96-5
Purity: ≥99%
Molecular Weight: 404.48
Molecular Formula: C23H20N2O3S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sulfinpyrazone is a free radical scavenger that is an inhibitor of organic anion transporters (OATP) and is an effective uricosuric chemical. It is a proposed nonselective UGT (UDP-glucuronosyltransferases) inhibitor. The transport of sulfinpyrazone in MDCKII-MRP1 cells is associated with GSH export, except in high concentrations, and is a substrate for MRP2 (multidrug resistance protein).


References

1. Evers, R., et al. 2000. Br. J. Cancer. 83: 375-383. PMID: 10917554
2. Yang, M.L., et al. 2002. Free Radic. Res. 36: 685-693. PMID: 12180194
3. Uchaipichat, V., et al. 2006. Drug Metab. Dispos. 34: 449-456. PMID: 16381668

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (partly), chloroform (1:2), ethyl acetate, acetone (100 mg/ml), and ethanol (1:40).
Storage :
Store at room temperature
Melting Point :
131-137° C
Boiling Point :
590.82° C at 760 mmHg (Predicted)
Density :
1.40 g/cm3 (Predicted)
Refractive Index :
n20D 1.72
IC50 :
FPR: IC50 = 10 µM (human); MRP5: IC50 = <100 µM (human); SLC22A12: IC50 = 100 µM (human); Cytochrome P450 51: IC50 = >200 µM (human)
pK Values :
pKa: 1.4 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UQ8575000
PubChem CID :
5342
Merck Index :
14: 8949
MDL Number :
MFCD00057279
EC Number :
200-357-4
Beilstein Registry :
713597
SMILES :
C1=CC=C(C=C1)N2C(=O)C(C(=O)N2C3=CC=CC=C3)CCS(=O)C4=CC=CC=C4

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Certificate of Analysis

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(±)-Sulfinpyrazone  Product Citations

See how others have used (±)-Sulfinpyrazone. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25862090  Dagvadorj, J. et al. 2015. Immunity. 42: 640-653.

Citations 1 to 1 of 1 total

Dear Mr/Ms, I would like to ask you what this the best solvant for preparing aqeous sulfinpyrazone? I have tried with Aqua dest or milliQ water but it was partly soluble in! Thanks for your help.

Asked by: Leonce
Thank you for your question. This chemical, (&plusmn;)-Sulfinpyrazone, CAS# 57-96-5, is soluble in ethanol and acetone (100 mg/mL - clear faint yellow solution).
Answered by: Technical Support
Date published: 2017-03-20
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Rated 5 out of 5 by from Uchalpichat et al Uchalpichat et al. (PubMed ID 16381668) used sulfinpyrazone to inhibit human UDP-glucuronosyltransferase. -SCBT Publication Review
Date published: 2015-02-11
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