Sulfinpyrazone is a free radical scavenger that is an inhibitor of organic anion transporters (OATP) and is an effective uricosuric chemical. It is a proposed nonselective UGT (UDP-glucuronosyltransferases) inhibitor. The transport of sulfinpyrazone in MDCKII-MRP1 cells is associated with GSH export, except in high concentrations, and is a substrate for MRP2 (multidrug resistance protein).
1. Evers, R., et al. 2000. Br. J. Cancer. 83: 375-383. PMID: 10917554 2. Yang, M.L., et al. 2002. Free Radic. Res. 36: 685-693. PMID: 12180194 3. Uchaipichat, V., et al. 2006. Drug Metab. Dispos. 34: 449-456. PMID: 16381668
Soluble in water (partly), chloroform (1:2), ethyl acetate, acetone (100 mg/ml), and ethanol (1:40).
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