(+/-)-Methoxyverapamil HydrochlorideA selective calcium channel protein inhibitor

(±)-Methoxyverapamil Hydrochloride (CAS 16662-47-8)

(±)-Methoxyverapamil Hydrochloride | CAS 16662-47-8 is rated 5.0 out of 5 by 1.
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Synonym: (±)-α-[3-[(2-(3,4-Dimethoxyphenyl)ethyl)methylamino]propyl]-3,4,5-trimethoxy-α-(1-methylethyl)benzeneacetonitrile hydrochloride
Application: A selective calcium channel protein inhibitor
CAS Number: 16662-47-8
Purity: ≥98%
Molecular Weight: 521.1
Molecular Formula: C28H40N2O5 HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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(±)-Methoxyverapamil Hydrochloride is a selective calcium channel protein inhibitor.


References

Daly, J.W., et al. 1995. Biochem. Pharmacol. 50, 1187. Ellory, J.C., et al. 1992. Br. J. Pharmacol. 106, 972. Meucci, O., et al. 1992. J. Neurochem. 59, 679. Soergel, D.G., et al. 1992. Mol. Pharmacol. 41, 487. Yokoyama, A., et al. 1988. J. Biochem. 104, 184.

Physical State :
Solid
Solubility :
Soluble in water, and methanol.
Storage :
Store at room temperature
Melting Point :
136° C
Boiling Point :
605.9° C at 760 mmHg (Predicted)
IC50 :
maitotoxin-induced Ca2+ influx : IC50 = 16 µM (3T3 cells)
pK Values :
pKb: 8.96 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
119442
Merck Index :
14: 4356
MDL Number :
MFCD00058000
SMILES :
CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C(=C2)OC)OC)OC.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Eberhardson Eberhardson, M. et al. (PubMed 10463099) reported that glucose and tolbutamide trigger transients of Ca2+ in single pancreatic beta-cells exposed to tetraethylammonium. They found that blockage of voltage-dependent Ca2+ channels with ( )-Methoxyverapamil resulted in a prompt disappearance of the transients induced by glucose or tolbutamide. -SCBT Publication Review
Date published: 2015-02-15
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