(±)-Clopidogrel hydrochloride is a thienopyridine adenosine diphosphate (ADP)-receptor antagonist. In addition, this ligand functions as a selective irreversible P2Y12 receptor antagonist. It is known that P2Y12 are ADP receptors located on platelet membranes and are responsible for platelet aggregation and cross-linking by fibrin. This mechanism involves blocking the activation of glycoprotein IIb/IIIa. It is known that (±)-Clopidogrel hydrochloride interacts with the ADP receptor by forming disulfide bonds. Furthermore, (±)-Clopidogrel hydrochloride is activated by cytochrome P450 enzymes from the liver, specifically CYP2C19.
1. Savi, P., et al. 2001. Biochem. Biophys. Res. Comm. 283: 379-383. PMID: 11327712
2. Savi, P. and Herbert, J.M. 2005. Semin. Thromb. Haemostas. 31: 174-183. PMID: 15852221
3. Von Kugelgen, I. 2006. Pharmacol. Ther. 110: 415-432. PMID: 16257449