(+/-)-Clopidogrel hydrochlorideCAS: 90055-48-4
MF: C16H16NO2SCl•HCl
MW: 358.28
A high affinity, selective P2Y12 receptor antagonist.

(±)-Clopidogrel hydrochloride (CAS 90055-48-4)

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Synonym: Plavix; Methyl 2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate hydrochloride
Application: A high affinity, selective P2Y12 receptor antagonist
CAS Number: 90055-48-4
Molecular Weight: 358.28
Molecular Formula: C16H16NO2SCl•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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(±)-Clopidogrel hydrochloride is a thienopyridine adenosine diphosphate (ADP)-receptor antagonist. In addition, this ligand functions as a selective irreversible P2Y12 receptor antagonist. It is known that P2Y12 are ADP receptors located on platelet membranes and are responsible for platelet aggregation and cross-linking by fibrin. This mechanism involves blocking the activation of glycoprotein IIb/IIIa. It is known that (±)-Clopidogrel hydrochloride interacts with the ADP receptor by forming disulfide bonds. Furthermore, (±)-Clopidogrel hydrochloride is activated by cytochrome P450 enzymes from the liver, specifically CYP2C19.


1. Savi, P., et al. 2001. Biochem. Biophys. Res. Comm. 283: 379-383. PMID: 11327712
2. Savi, P. and Herbert, J.M. 2005. Semin. Thromb. Haemostas. 31: 174-183. PMID: 15852221
3. Von Kugelgen, I. 2006. Pharmacol. Ther. 110: 415-432. PMID: 16257449

Physical State :
Solubility :
Soluble in DMSO (100 mM), ethanol (100 mM), DMF (~20 mg/ml), and DMSO:PBS (1:2, pH 7.2) (~0.33 mg/ml).
Storage :
Desiccate at 4° C
Refractive Index :
n20D 1.62 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :

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Certificate of Analysis

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