(+/-)alpha-Methylserotonin maleateA SR-2A, SR-2B, and SR-2C agonist

(±)alpha-Methylserotonin maleate (CAS 304-52-9)

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Application: A SR-2A, SR-2B, and SR-2C agonist
CAS Number: 304-52-9
Molecular Weight: 306.3
Molecular Formula: C11H14N2O.C4H4O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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(±)α-Methylserotonin maleate is a racemic mixture of α-Methylserotonin maleate and is a serotonin (SR) receptor agonist with preference for SR-2A, SR-2B, and SR-2C. (±)α-Methylserotonin maleate has been utilized in studies of aggression involving the central amygdaloid nucleus in female Wistar rats. Additional studies with frog spinal cord motoneurons in the presence of NMDA receptor open-channel blockers and high concentrations of α-methy-5-hydroxytryptamine indicated that these high concentrations significantly potentiated NMDA-induced depolarizations in these motoneurons.


1. Ismaiel, A.M., et al. 1990. J. Med. Chem. 33: 755-758. PMID: 2299641
2. Wilson, H., et al. 1990. J. Pharmacol. Exp. Ther. 252: 683-688. PMID: 1968974
3. Holohean, A.M. and Hackman, J.C. 2004. Br. J. Pharmacol. 143: 351-360. PMID: 15339859
4. de Almeida, R.M., et al. 2006. Rev Bras Psiquiatr. 28: 130-134. PMID: 16810397

Physical State :
Solubility :
Soluble in water (10 mg/ml), and DMSO (100 mM).
Storage :
Store at -20° C
Melting Point :
191-193° C
Boiling Point :
411.7° C at 760 mmHg (Predicted)
pK Values :
pKa: 10.01 (Predicted), pKb: 10.91 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :

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Certificate of Analysis

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