(+/-)9-HODEA distinct product of non-enzymatic linoleic acid oxidation

(±)9-HODE (CAS 98524-19-7)

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Synonym: (±)-9-hydroxy-10E,12Z-octadecadienoic acid
Application: A distinct product of non-enzymatic linoleic acid oxidation
CAS Number: 98524-19-7
Molecular Weight: 296.5
Molecular Formula: C18H32O3
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* Refer to Certificate of Analysis for lot specific data (including water content).
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(±)9-HODE is one of the two racemic monohydroxy fatty acids resulting from the non-enzymatic oxidation of linoleic acid. Approximately equal proportions of both isomers are found in plasma and mitochondrial membranes of rabbit reticulocytes. Oxidized LDL contains significant amounts of esterified 9- and 13-HpODEs and HODEs.


References

1 Kühn, H., Belkner, J., Wiesner, R. Subcellular distribution of lipoxygenase products in rabbit reticulocyte membranes. Eur J Biochem 191 221-227 (1990). 2 Kühn, H., Belkner, J., Wiesner, R. Metabolism of polyenoic fatty acids by rabbit reticulocytes. Intracellular action of the erythroid lipoxygenase on membrane lipids. Biomed Biochim Acta 49 S25-S30 (1990). 3 Folcik, V.A., Cathcart, M.K. Predominance of esterified hydroperoxy-linoleic acid in human monocyte-oxidized LDL. J Lipid Res 35 1570-1582 (1994). 4 Ku, G., Thomas, C.E., Akeson, A.L., et al. Induction of interleukin 1β expression from human peripheral blood monocyte-derived macrophages by 9-hydroxyoctadecadienoic acid. J Biol Chem 267 14183-14188 (1992).

Formulation :
A solution in ethanol
Physical State :
Liquid
Solubility :
Soluble in DMSO (~50 mg/ml), DMF (~50 mg/ml), PBS (pH 7.2) (~1 mg/ml), ethanol (50 µg/ml), and water (>1 mg/ml at 25.0° C).
Storage :
Store at -20° C
Boiling Point :
78° C
Refractive Index :
n20D 1.49 (Predicted)
IC50 :
CRM1 interaction with HIV1 HA-tagged Rev: IC50 = 7.20 µM (HeLa cells)
pK Values :
pKa: 4.78 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5282944
MDL Number :
MFCD00065830
SMILES :
CCCCC/C=C\\C=C\\C(CCCCCCCC(=O)O)O

Download SDS (MSDS)

Certificate of Analysis

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